CTC - Center for Cell-Based Therapy

• Grant number: 13/08135-2
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• Duration: June 01, 2013 - May 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Dimas Tadeu Covas
• Grantee: Dimas Tadeu Covas
• Host Institution: Hemocentro de Ribeirão Preto. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Secretaria da Saúde (São Paulo - Estado). Ribeirão Preto , SP, Brazil
• Pesquisadores principais:( Atuais ): Eduardo Magalhães Rego ; Fabíola Traina ; Flávio Vieira Meirelles ; Lewis Joel Greene ; Lygia da Veiga Pereira ; Marco Antonio Zago ; Maria Carolina de Oliveira Rodrigues ; Roberto Passetto Falcão ; Rodrigo do Tocantins Calado de Saloma Rodrigues ; Vanderson Geraldo Rocha ; Vitor Marcel Faça ; Wilson Araújo da Silva Junior
• Pesquisadores principais:( Anteriores ): Dimas Tadeu Covas
• Associated researchers: Andréia Machado Leopoldino ; Ângela Merice de Oliveira Leal ; Antonio Roberto Lucena de Araújo ; Bart Roep ; Belinda Pinto Simoes ; Carlos Eduardo Ambrósio ; Christina Ramires Ferreira ; Clarice Izumi ; Daniele dos Santos Martins ; Davide Ruggero ; Dominique Farge ; Elisa Maria de Sousa Russo ; Fabíola Traina ; Felipe Perecin ; Gene Yeo ; Gerhard Coetzee ; Hau Kwaan ; Houtan Noushmehr ; Jeanne Loring ; Joanna Poulton ; José César Rosa ; Kamilla Swiech Antonietto ; Kelen Cristina Ribeiro Malmegrim de Farias ; Lawrence Charles Smith ; Lucas Eduardo Botelho de Souza ; Lygia da Veiga Pereira ; Maria Angelica Miglino ; Maria Carolina de Oliveira Rodrigues ; Marisa Ramos Barbieri ; Marjorie Barnett ; Renato Luiz Guerino Cunha ; Richard Burt ; Rodrigo Alexandre Panepucci ; Simone Kashima Haddad ; Stefan Bohlander ; Valeria Valente ; Virginia Picanço e Castro ; Vitor Marcel Faça ; Willian Alan King
• Associated grant(s): 19/27075-7 - Oocyte epigenetic maturation and totipotency - the oocyte competence and its relationship with the ovarian follicular niche, AV.EXT; 20/05367-3 - Convalescent donor plasma to treat patients with severe SARS-CoV-2 infection (COVID-19), AP.R; 18/00440-4 - iPSCs: A Decade of Progress and Beyond, AR.EXT; + associated grants 16/22858-5 - Scale-up and Manufacturing of Cell-based Therapies V, AR.EXT; 15/50339-0 - Building metabolomics capacity in livestock research: focus on cattle and application to reproductive biotechnology, AP.R SPRINT; 14/23427-2 - Multi-User Equipment approved in grant 2013/08135-2 equipment: flow cytometer with cell Soter accessories, AP.EMU; 13/50385-6 - Integrated transcriptome and methylome analysis of undifferentiated and differentiated Brazilian pluripotent cell lines, AP.R - associated grants
• Associated scholarship(s): 23/04099-3 - Administrative training in monitoring, control of acquisitions financial execution of resources preparation of accountability in a research project., BP.TT; 22/09926-2 - Evaluation of GITRL coexpression on the therapeutic efficiency and immunossupression resistance of anti-GD2 CAR-T cells in a preclinical model of Glioblastoma Multiforme, BP.DD; 22/07503-7 - Episomal vector Zif-VP64 analysis as an HbF inducer for treatment of sickle cell anemia using gene therapy., BP.DR; + associated scholarships 22/09764-2 - CRISPR mediated-tagging of endogenous RMEL3 lncRNA for study of its molecular interactions and subcellular localization, BP.IC; 22/09643-0 - Immunophenotypic and functional analysis of circulating CD34 cells in patients with sickle cell anemia under chronic transfusion or Hydroxyurea regimen., BP.IC; 22/08235-6 - Administrative training in monitoring, control of acquisitions and stock of research materiais, BP.TT; 21/06359-7 - Anti-MAGE-A4 CAR-NK cell therapy for the treatment of Melanoma, BP.DR; 21/05465-8 - Genetic modification of NK cells with anti-CD19 CAR expressing GITRL to increase NK cells effector function for leukemias and lymphomas treatment, BP.DR; 22/03271-4 - Animal models for studying cancer, BP.TT; 21/11568-4 - Assessment of the effect of KMT2E expression in Acute Myeloid Leukemia on the response to all trans-retinoic acid (ATRA) and SLIT2 treatment, BP.DD; 21/08755-7 - Effect of UM171 on the in vitro expansion of hematopoietic stem cells from patients with telomeropathies, BP.DR; 20/13463-2 - Proteomic and phosphoproteomic analysis of molecular mechanisms and signaling for Anti CD-19 CAR-T cell therapy in Leukemia and Lymphoma, BP.DD; 20/03108-0 - Establishment of the in vitro cardiovascular model derived from human Pluripotent Stem Cells (hiPSCs) for functional analysis of Hypertension, BP.DR; 19/26007-8 - Endothelial phenotype as determinant of genotype/phenotype relationship in Marfan Syndrome, BP.PD; 21/06467-4 - Administrative training in monitoring, control of acquisitions and stock of research materials, BP.TT; 20/11413-8 - Development of a new immunotherapy approach for solid tumors using T cells genetically modified to express a novel anti-NY-ESO-1 engineered TCR, BP.DR; 21/01462-4 - Immunophenotypic characterization of stem-cells and hematopoietic progenitors compartments in patients with telomeropathies, BP.IC; 21/04120-7 - Animal models for cancer studies, BP.TT; 21/03976-5 - Administrative training in monitoring, control of acquisitions and stock of research materials, BP.TT; 21/03063-0 - Technical and improvement training in the legal area, in order to collaborate to increase the general legal advisory activities, ensuring legal security in the planning and execution of business, BP.TT; 21/02211-5 - Administrative training in monitoring, control of acquisitions financial execution of resources preparation of accountability in a research project, BP.TT; 20/09206-4 - Prospection of technological trends in immunotherapy in the area of gene therapy, BP.DR; 20/13460-3 - Administrative training in monitoring, control of acquisitions and preparation of accountability in research project, BP.TT; 20/08279-8 - Establishment of a platform for generating NK-CAR cells with greater therapeutic effectiveness in vitro and in vivo, BP.PD; 20/10804-3 - Development and validation of anti-BCMA CAR-T cells with memory profile for Multiple Myeloma treatment, BP.PD; 20/02043-2 - Development of CRISPR/Cas9-based genome editing for the generation of allogeneic CAR-T cells, BP.MS; 19/22155-2 - Cellular characterization of hematopoietic niches in murine model of sickle cell anemia, BP.MS; 19/05722-0 - Investigation of cellular and molecular effects of metformin treatment in rare myeloid neoplasms, BP.DR; 19/18702-8 - Generation and evaluation of antitumor efficiency of CAR-T cells harboring a T helper 17 phenotype, BP.MS; 19/18672-1 - Evaluation of in vivo persistence of T lymphocytes expressing anti-CD19 chimeric antigen receptors, BP.IC; 19/14084-8 - Investigation of the role of SLIT2 protein in mesenchymal stromal cells and its influence on the bone marrow microenvironment in acute myeloid leukemia, BP.MS; 19/04738-0 - LncRNAs in bovine early embryo development and during SCNT reprograming, BP.PD; 19/01285-5 - Post-translational regulation of RAS by the EMC complex: a potential target for anti-oncogenic therapy, BP.DR; 18/16254-5 - Analysis of the FBN1 effect in hiPSC derived endothelial cells, BP.IC; 18/14897-6 - Generation of human endothelial cells derived from hiPSC lineages with FBN1 mutations, BP.IC; 17/24027-6 - Analysis of gene pathways regulated by the HOXB2 gene in glioblastoma, BP.MS; 18/04232-7 - Functional analysis of extracellular vesicles derived from human mesenchymal stromal cell used in cell therapy, BP.MS; 17/12140-2 - X-chromosome status during blood cells reprogramming in human induced pluripotent cells (iPSCs) and generation of in vitro primordial germ cells (iPGCs)., BP.PD; 17/21737-2 - HEK-293T cell line adaptation for suspension and serum free culture medium for large-scale production of lentiviral vectors, BP.IC; 17/08057-2 - The globin switching of the in vitro hematopoietic differentiation, BP.MS; 17/15208-7 - Investigation of HJURP functions in the acquisition of stemness in glioblastoma lines, BP.DR; 17/19825-0 - Mechanisms of oocyte lipid accumulation in obesity, BP.PD; 17/12663-5 - In vivo characterization of murine mesenchymal stem cells from bone marrow and compact bone in relation to its heterotopic hematopoietic niche generation potential, BP.MS; 16/24443-7 - Immunophenotypic, functional and gene evaluation of B cell subsets in patients with systemic sclerosis undergoing autologous hematopoietic stem cell transplantation, BP.DR; 17/09428-4 - Clonal hematopoiesis in patients with telomeric dysfunction, BP.PD; 17/03102-0 - Analysis of the impact of HJURP silencing on the control of replicative stress in GBM cells, BP.IC; 17/09491-8 - Murine Leukemia/Lymphoid Lymphoma models for evaluating antitumor effects of CAR-CD19-modified T cells, BP.PD; 16/22790-1 - Extracellular vesicles in inter-embryonic and maternal-embryonic communication during in vitro development of bovine embryos, BP.PD; 16/20650-8 - Assessment of hIPSC- derived hepatocytes as a model to study the responsiveness losartan in vitro, BP.MS; 16/13416-9 - Use of the ketone body beta-hydroxybutyric acid as an experimental tool to study the link among metabolism, epigenetic and reproduction in cattle, BP.PD; 15/23469-0 - Identifying sickle cell anemia modifying genes by exome analysis, BP.PD; 16/10862-8 - Study of myosin-Va role in the processes of mitochondrial dynamics and mitophagy, BP.DD; 16/08374-5 - Modification of T cells with anti-CD19 chimeric antigen receptor, BP.MS; 16/08373-9 - Obtaintion of erythrocytes from induced pluripotent stem cells in feeder-free culture with xeno-free culture medium, BP.MS; 15/16329-7 - In vitro analysis of the role of HOXA10, HOXC9, HOXC10 and HOXC13 genes in tumorigenesis of head and neck cancer, BP.IC; 15/08070-3 - Large-scale analysis of microRNA function in cell cycle, pluripotency, self-renewal and differentiation of stem cells using high-content screening, BE.PQ; 15/15225-3 - Evaluation of metabolic and gene expression profiles of hepatocytes obtained from induced pluripotent stem cells (iPSC) from human patients with telomeropathies, BP.PD; 15/08807-6 - H3K9 methylation as regulator of epigenetic memory on bovine nuclear reprograming., BP.PD; 15/09575-1 - Gene edition by CRISPR-Cas9 in the correction of Duchenne muscular dystrophy in a canine model (GRMD) from induced pluripotent stem cells, BP.PD; 14/24587-3 - Comparative analyses of induced pluripotent stem cell-derived neurons from patients with Gaucher disease and Parkinson, BP.DR; 15/01046-0 - In vitro toxicity screening using human embryonic pluripotent stem cells, BP.IC; 14/27294-7 - Identification of genetic factors of response to immunosuppression in acquired aplastic anemia by next generation sequencing, BP.DR; 14/26379-9 - Mutational analysis of GATA2 gene and immunological alterations in patientes with bone marrow failure, BP.MS; 14/20756-5 - Functional high-throughput screening for the identification of microRNAs with antitumor and antimetastatic potential in head and neck cancer, BP.DR; 14/20379-7 - Gene expression profiling of HOX genes family in a panel of 70 cancer cell lines, BP.IC; 14/00088-8 - Haematological and immunological mechanisms involved in the therapeutic response of patients with sickle cell anemia submitted to allogeneic hematopoietic stem cell transplantation, BP.DR; 13/25119-0 - Energetic metabolism study on melanoma progression based on mitochondrial genome instability, BP.DR; 14/07726-0 - Genomic and functional characterization of genes with expression restricted to melanoma (RMELs), BP.DD; 14/03866-1 - Evaluation of thymic function in patients with sickle cell anemia, BP.DR; 14/02574-7 - Study of the mechanisms of generation of Regulatory T cells from naive t cells: the role of adenosine signaling, BP.DR; 13/27061-0 - The role of microRNAs on the proliferation and cell differentiation of the embryonal carcinoma pluripotent cell line NTera-2., BP.DR; 13/24199-0 - Evaluation of TERRA expression levels and its correlation with the telomeric imbalance in patients with hemopathies and telomeropathies., BP.DR; 13/11817-8 - Aditional mutations to the PML-RARa gene rearrangement by transcriptome, whole-exome and metilome analysis in Acute Promyelocytic Leukemia samples obtained at diagnosis, molecular remission and relapse time, BP.PD; 13/18678-3 - Study of immunological mechanisms involved in the therapeutic response of patients with systemic sclerosis to autologous hematopoietic stem cells transplantation, BP.DR; 13/07675-3 - Study of PI3K/AKT signaling pathways in acute myeloid leukemia using selective ion monitoring (SRM)., BP.PD - associated scholarships

Abstract

We propose a program of basic and clinical research to isolate, culture, and characterize embryonic ,somatic, and neoplastic stem cells in order to understand their biology and apply this knowledge to therapy, comprising four research lines: (1) pluripotent stem cells (SC) (embryonic SC and induced pluripotent SC); (2) somatic SC (hematopoietic SC, mesenchymal SC, endothelial SC, and cancer SC); (3)general mechanisms involved in maintaining "stemness"; and (4) clinical SC applications. This research plan is firmly grounded in the analysis of mechanisms and pathways of normal and abnormal stem cells to serve as targets or to help manipulate cells for therapy. The research team includes specialists in cell and molecular biology, embryology, genomics, bioinformatics, veterinary medicine, hematology, and oncology. The technology transfer plan involves cooperation with the private sector and with the government, the education of a new generation of scientists and technicians, and the direct transfer of high quality services to the public. The education plan is focused mainly in a long-term relationship of teachers and middle-school students with the center, researchers, and PhD students. (http://ctcusp.org/) (AU)

Scientific publications

(177)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GODOY PIERI, NAIRA CAROLINE; DE SOUZA, ALINE FERNANDA; BOTIGELLI, RAMON CESAR; MACHADO, LUCAS SIMOES; AMBROSIO, CARLOS EDUARDO; MARTINS, DANIELE DOS SANTOS; CESAR DE ANDRADE, ANDRE FURUGEN; MEIRELLES, FLAVIO VIEIRA; HYTTEL, POUL; BRESSAN, FABIANA FERNANDES. Stem cells on regenerative and reproductive science in domestic animals. VETERINARY RESEARCH COMMUNICATIONS, v. 43, n. 1, p. 7-16, FEB 2018. (13/08135-2, 13/09392-9, 12/01060-4, 15/26818-5)

RAFAEL GARCIA KARAM; LINA CASTELO BRANCO MOTTA; MATHEUS FERREIRA DE ALMEIDA; ALESSANDRA BRIDI; JULIANO COELHO DA SILVEIRA; CARLOS EDUARDO AMBRÓSIO. Secretion pattern of canine amniotic stem cells derived extracellular vesicles. Animal Reproduction, v. 19, n. 4, 2022-11-14. (17/21266-0, 13/08135-2)

MOREIRA, FRANCISCO; MIZUKAMI, AMANDA; DE SOUZA, LUCAS EDUARDO BOTELHO; CABRAL, JOAQUIM M. S.; DA SILVA, CLAUDIA L.; COVAS, DIMAS T.; SWIECH, KAMILLA. Successful Use of Human AB Serum to Support the Expansion of Adipose Tissue-Derived Mesenchymal Stem/Stromal Cell in a Microcarrier-Based Platform. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 8, APR 15 2020. (13/08135-2, 12/23228-4)

SOUSA, LUCAS OLIVEIRA; SOBRAL, LAYS MARTIN; DE ALMEIDA, LUCIANA OLIVEIRA; GARCIA, CRISTIANA BERNADELLI; GREENE, LEWIS JOEL; LEOPOLDINO, ANDREIA MACHADO. SET protein modulates H4 histone methylation status and regulates miR-137 level in oral squamous cell carcinoma. Epigenomics, v. 12, n. 6, p. 475-485, MAR 2020. (10/20384-0, 16/19103-2, 13/10898-4, 13/08135-2)

LANGE, ANA P.; LIMA, ANA S.; LUCENA-ARAUJO, ANTONIO R.; JACOMO, RAFAEL H.; MELO, RAUL A.; BITTENCOURT, ROSANE I.; PASQUINI, RICARDO; PAGNANO, KATIA; FAGUNDES, EVANDRO M.; CHAUFFAILLE, MARIA L.; et al. The experience of the International Consortium on Acute Promyelocytic Leukemia in monitoring minimal residual disease in acute promyelocytic leukaemia. British Journal of Haematology, v. 180, n. 6, p. 915-918, MAR 2018. (11/17111-4, 13/08135-2)

SILVESTRINI, VIRGINIA CAMPOS; LANFREDI, GUILHERME PAUPERIO; MASSON, ANA PAULA; POERSCH, ALINE; FERREIRA, GERMANO AGUIAR; THOME, CAROLINA HASSIBE; FACA, VITOR MARCEL. A proteomics outlook towards the elucidation of epithelial-mesenchymal transition molecular events. MOLECULAR OMICS, v. 15, n. 5, p. 316-330, OCT 1 2019. (17/03960-6, 16/03809-3, 13/08135-2)

GUTIERREZ-RODRIGUES, FERNANDA; MASRI, NOHAD; CHOUERY, ELIANE; DIAMOND, CARRIE; JALKH, NADINE; VICENTE, ALANA; KAJIGAYA, SACHIKO; ABILLAMA, FAYEZ; BEJJANI, NOHA; SERHAL, WASSIM; et al. A novel homozygous RTEL1 variant in a consanguineous Lebanese family: phenotypic heterogeneity and disease anticipation. Human Genetics, v. 138, n. 11-12, p. 1323-1330, DEC 2019. (13/08135-2)

JULIANA FERREIRA DE SOUSA; RODOLFO BORTOLOZO SERAFIM; LAURA MARISE DE FREITAS; CARLA RAQUEL FONTANA; VALERIA VALENTE. DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 1, 2019-12-13. (13/08135-2, 16/05345-4, 13/13465-1, 18/05018-9, 14/24581-5)

ROSS, PABLO J.; SAMPAIO, RAFAEL V.. Epigenetic remodeling in preimplantation embryos: cows are not big mice. ANIMAL REPRODUCTION, v. 15, n. 3, p. 204-214, JUL-SEP 2018. (13/08135-2, 15/08807-6)

MIZUKAMI, AMANDA; PEREIRA CHILIMA, TANIA D.; ORELLANA, MARISTELA D.; ABREU NETO, MARIO; COVAS, DIMAS T.; FARID, SUZANNE S.; SWIECH, KAMILLA. Technologies for large-scale umbilical cord-derived MSC expansion: Experimental performance and cost of goods analysis. Biochemical Engineering Journal, v. 135, p. 36-48, JUL 15 2018. (13/23599-5, 13/08135-2, 12/23228-4)

RODRIGUES, EVANDRA STRAZZA; FAVARIN, MARIA DO CARMO; DE MACEDO, MAYRA DORIGAN; OTAGUIRI, KATIA KAORI; ORELLANA, MARISTELA DELGADO; TAKAYANAGUI, OSVALDO MASSAITI; BONINI PALMA, PATRICIA VIANNA; SLAVOV, SVETOSLAV NANEV; COVAS, DIMAS TADEU; KASHIMA, SIMONE. Detection of HTLV-1 proviral DNA in BM mononuclear cells and cultured mesenchymal stromal cells isolated from patients with HTLV-1 infection. VIROLOGY, v. 519, p. 145-155, JUN 2018. (13/08135-2)

ARTHUR, RODRIGO ALEX; BEZERRA, RAFAEL DOS SANTOS; BIANCHI XIMENEZ, JOAO PAULO; MERLIN, BRUNA LAIS; MORRAYE, RAPHAEL DE ANDRADE; NETO, JOAO VALENTINI; NASSER FAVA, NATALIA MELO; ALVES FIGUEIREDO, DAVID LIVINGSTONE; OLIVEIRA DE BIAGI JR, CARLOS ALBERTO; MONTIBELLER, MARIA JARA; et al. Microbiome and oral squamous cell carcinoma: a possible interplay on iron metabolism and its impact on tumor microenvironment. Brazilian Journal of Microbiology, v. 52, n. 3, p. 1287-1302, SEP 2021. (19/08528-0, 17/23205-8, 13/08135-2)

ALVES-SILVA, ANTONIO BRUNO; FENERICH, BRUNA ALVES; FONSECA, NATASHA PEIXOTO; FERNANDES, JAQUELINE CRISTINA; COELHO-SILVA, JUAN LUIZ; PEREIRA-MARTINS, DIEGO ANTONIO; BIANCO, THIAGO MANTELLO; SCHEUCHER, PRISCILA SANTOS; REGO, EDUARDO MAGALHAES; CHAHUD, FERNANDO; et al. Phenformin increases early hematopoietic progenitors in the Jak2(V617F) murine model. INVESTIGATIONAL NEW DRUGS, JAN 2022. (14/50947-7, 13/08135-2)

CATTO, LUIZ FERNANDO B.; BORGES, GUSTAVO; PINTO, ANDRE L.; CLE, DIEGO V.; CHAHUD, FERNANDO; SANTANA, BARBARA A.; DONAIRES, FLAVIA S.; CALADO, RODRIGO T.. Somatic genetic rescue in hematopoietic cells in GATA2 deficiency. Blood, v. 136, n. 8, p. 1002-1005, AUG 20 2020. (14/26379-9, 13/08135-2, 17/09428-4)

MARTINS ROCHA, JOSE LUCAS; FERREIRA DE OLIVEIRA, WALDIR CESAR; NORONHA, NADIA CASSIA; DIAS DOS SANTOS, NATALIA CRISTINE; COVAS, DIMAS TADEU; PICANCO-CASTRO, VIRGINIA; SWIECH, KAMILLA; RIBEIRO MALMEGRIM, KELEN CRISTINA. Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19. STEM CELL REVIEWS AND REPORTS, v. 17, n. 1, SI, SEP 2020. (13/08135-2)

MASTELLOS, DIMITRIOS C.; PIRES DA SILVA, BRUNO G. P.; FONSECA, BENEDITO A. L.; FONSECA, NATASHA P.; AUXILIADORA-MARTINS, MARIA; MASTAGLIO, SARA; RUGGERI, ANNALISA; SIRONI, MARINA; RADERMACHER, PETER; CHRYSANTHOPOULOU, AKRIVI; et al. Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy. Clinical Immunology, v. 220, NOV 2020. (13/08135-2)

HENRIQUE-NETO, ALVARO; VASCONCELOS, MARIANNA YUMI KAWASHIMA; DIAS, JULIANA BERNARDES ELIAS; DE MORAES, DANIELA APARECIDA; GONCALVES, MAYNARA SANTANA; ZANIN-SILVA, DJULIO CESAR; ZUCOLOTO, TALITA GRAMINHA; DE OLIVEIRA, MARILIA DE FATIMA CIRIOLI; DOTOLI, GIULIANA MARTINELLI; WEFFORT, LUIZ FERNANDO; et al. Hematopoietic stem cell transplantation for systemic sclerosis: Brazilian experience. ADVANCES IN RHEUMATOLOGY, v. 61, n. 1, DEC 6 2021. (13/08135-2)

DE SOUSA, JULIANA FERREIRA; DA SILVA, PATRICK; SERAFIM, RODOLFO BORTOLOZO; NOCITI, RICARDO PERECIN; MOREIRA, CRISTIANO GALLINA; SILVA, WILSON ARAUJO; VALENTE, VALERIA. RNA sequencing data of different grade astrocytoma cell lines. DATA IN BRIEF, v. 34, FEB 2021. (13/08135-2, 13/13465-1, 18/05018-9)

BOTELHO DE SOUZA, LUCAS EDUARDO; FERREIRA, FERNANDA URSOLI; THOME, CAROLINA HASSIBE; BRAND, HELOISA; ORELLANA, MARISTELA DELGADO; FACA, VITOR MARCEL; FONTES, APARECIDA MARIA; COVAS, DIMAS TADEU. Human and mouse melanoma cells recapitulate an EMT-like program in response to mesenchymal stromal cells secretome. Cancer Letters, v. 501, p. 114-123, MAR 31 2021. (19/18702-8, 08/08944-0, 13/08135-2)

FENERICH, BRUNA ALVES; FERNANDES, JAQUELINE CRISTINA; RODRIGUES ALVES, ANA PAULA NUNES; COELHO-SILVA, JUAN LUIZ; SCOPIM-RIBEIRO, RENATA; SCHEUCHER, PRISCILA SANTOS; EIDE, CHRISTOPHER A.; TOGNON, CRISTINA E.; DRUKER, BRIAN J.; REGO, EDUARDO MAGALHAES; et al. NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2(V617F)-positive myeloproliferative neoplasm cells. SIGNAL TRANSDUCTION AND TARGETED THERAPY, v. 5, n. 1, JAN 24 2020. (15/09324-9, 15/02200-2, 13/08135-2, 14/50947-7)

CARVALHO, KAREN F.; MACHADO, THIAGO S.; GARCIA, BRUNA M.; ZANGIROLAMO, AMANDA F.; MACABELLI, CAROLINA H.; SUGIYAMA, FABRICIA H. C.; GREJO, MATEUS P.; NETO, J. DJACI AUGUSTO; TOSTES, KATIANE; RIBEIRO, FERNANDA K. S.; et al. Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells. FASEB JOURNAL, v. 34, n. 6, APR 2020. (12/50231-6, 16/11935-9, 09/54035-4, 13/08135-2, 17/04372-0, 16/11942-5, 16/07868-4)

ANDRADE, GABRIELLA MAMEDE; DEL COLLADO, MAITE; MEIRELLES, FLAVIO VIEIRA; DA SILVEIRA, JULIANO COELHO; PERECIN, FELIPE. Intrafollicular barriers and cellular interactions during ovarian follicle development. ANIMAL REPRODUCTION, v. 16, n. 3, p. 485-496, JUL-SEP 2019. (18/01431-9, 18/13155-6, 17/19825-0, 14/22887-0, 13/08135-2)

ROSSETTI, RAFAELA; ROS, FELIPE AUGUSTO; BOTELHO DE SOUZA, LUCAS EDUARDO; MACONETTO, JULIANA DE MATOS; MENDES DA COSTA, PERICLES NATAN; FERREIRA, FERNANDA URSOLI; BORGES, JOSIANE SERRANO; DE CARVALHO, JULIANNE VARGAS; MOROTTI, NAYARA PATRICIA; KASHIMA, SIMONE; et al. Hypoxia-cultured mouse mesenchymal stromal cells from bone marrow and compact bone display different phenotypic traits. Experimental Cell Research, v. 399, n. 1, FEB 1 2021. (17/12663-5, 15/19018-2, 13/08135-2)

DE CASTRO, RAQUEL V. G.; PIERI, NAIRA C. G.; FANTINATO NETO, PAULO; GRIZENDI, BIANCA M.; DORIA, RENATA G. S.; MEIRELLES, FLAVIO V.; SMITH, LAWRENCE C.; GARCIA, JOAQUIM M.; BRESSAN, FABIANA F.. In Vitro Induction of Pluripotency from Equine Fibroblasts in 20% or 5% Oxygen. STEM CELLS INTERNATIONAL, v. 2020, NOV 26 2020. (13/08135-2, 18/04009-6, 15/26818-5)

DE FIGUEIREDO-PONTES, LORENA LOBO; AYROSA MADEIRA, MARIA ISABEL; CORREA DE ARAUJO, LUISA KOURY; SCHEUCHER, PRISCILA SANTOS; TRAINA, FABIOLA; GOUVEA DE LIMA, ANA SILVIA; PAGNANO, KATIA; PALLOTA, RONALD; BITTENCOURT, ROSANE; CHAUFFAILLE, MARIA DE LOURDES; et al. Feasibility of minimal residual disease studies by multiparametric flow cytometry for acute myeloid leukemia in a developing country. BLOOD ADVANCES, v. 1, n. 1, p. 80-83, DEC 8 2017. (13/08135-2)

E LIMA BUENO, RAFAELA DE BARROS; RAMAO, ANELISA; PINHEIRO, DANIEL GUARIZ; ALVES, CLEIDSON PADUA; KANNEN, VINICIUS; JUNGBLUTH, ACHIM A.; DE ARAUJO, LUIZA FERREIRA; MUYS, BRUNA RODRIGUES; FONSECA, ALINE SIMONETI; PLACA, JESSICA RODRIGUES; et al. HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma. TUMOR BIOLOGY, v. 37, n. 11, p. 15087-15096, NOV 2016. (13/08135-2)

CORREA DE FREITAS, MARCELA CRISTINA; BOMFIM, ALINE DE SOUSA; MIZUKAMI, AMANDA; PICANCO-CASTRO, VIRGINIA; SWIECH, KAMILLA; COVAS, DIMAS TADEU. Production Of coagulation factor VII in human cell lines Sk-Hep-1 and HBK-11. Protein Expression and Purification, v. 137, p. 26-33, SEP 2017. (11/01736-5, 13/08135-2, 16/02433-0)

JUNQUEIRA REIS, LUIZA CUNHA; PICANCO-CASTRO, VIRGINIA; MARTINS FERNANDES PAES, BARBARA CRISTINA; PEREIRA, OLIVIA AMBROZINI; GYURICZA, ISABELA GERDES; DE ARAUJO, FABIANO TOFOLI; MORATO-MARQUES, MARIANA; MOREIRA, LILIAN FIGUEIREDO; OLIVEIRA COSTA, EVERTON DE BRITO; MOREIRA DOS SANTOS, TYLITA POLLYANNA; et al. Induced Pluripotent Stem Cell for the Study and Treatment of Sickle Cell Anemia. STEM CELLS INTERNATIONAL, 2017. (13/08135-2)

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MUYS, BRUNA RODRIGUES; CETRULO LORENZI, JULIO CESAR; ZANETTE, DALILA LUCIOLA; LIMA E BUENO, RAFAELA DE BARROS; DE ARAUJO, LUZA FERREIRA; DINARTE-SANTOS, ANEMARI RAMOS; ALVES, CLEIDSON PADUA; RAMAO, ANELISA; DE MOLFETTA, GREICE ANDREOTTI; VIDAL, DANIEL ONOFRE; et al. Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line. PLoS One, v. 11, n. 3, MAR 29 2016. (13/08135-2, 11/04154-7)

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ARAUJO, LUIZA FERREIRA; MOLFETTA, GREICE ANDREOTTI; VINCENZI, OTAVIO COSTA; HUBER, JAIR; TEIXEIRA, LORENA ALVES; FERRAZ, VICTOR EVANGELISTA; SILVA JR, WILSON ARAUJO. Molecular basis of familial adenomatous polyposis in the southeast of Brazil: identification of six novel mutations. International Journal of Biological Markers, v. 34, n. 1, p. 80-89, MAR 2019. (13/08135-2, 09/53853-5, 11/11456-0, 13/25119-0)

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GOMES DE LIMA, SARAH CAROLINE; CARVALHO FANTACINI, DAIANNE MACIELY; BATISTA, LAIS DE CASTRO; SILVEIRA, ROBERTA MARANINCHI; FURTADO, IZADORA PETER; ROSSETTI, RAFAELA; BRAND, HELOISA; COVAS, DIMAS TADEU; BOTELHO DE SOUZA, LUCAS EDUARDO. Strategies to Enhance the Therapeutic Efficacy, Applicability, and Safety of Genetically Engineered Immune Cells. CRITICAL REVIEWS IN IMMUNOLOGY, v. 41, n. 1, SI, p. 41-67, 2021. (20/02043-2, 19/18702-8, 13/08135-2, 19/18672-1)

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