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Oocyte epigenetic maturation and totipotency - the oocyte competence and its relationship with the ovarian follicular niche

Grant number: 19/27075-7
Support type:Research Grants - Visiting Researcher Grant - International
Duration: January 02, 2021 - July 16, 2021
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Reproduction
Principal researcher:Flávio Vieira Meirelles
Grantee:Flávio Vieira Meirelles
Visiting researcher: Lawrence Charles Smith
Visiting researcher institution: Université de Montréal, Canada
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Associated research grant:13/08135-2 - CTC - Center for Cell-Based Therapy, AP.CEPID


The proposal aims at the participation of the visiting researcher in a series of projects coordinated by the involved team. Including CEPID, INCT, Young Investigators and Regular Projects. Collaboration with Dr. Smith has been around for a long time, and in the recent years it has helped the team to be recognized in this area. His knowledge in his field of nuclear reprogramming has been recognized since the work that began with the production of cloned animals at the Roslin Institute in the 1980s and more recently with epigenetic analysis, closely related to genomic imprinting in animals produced by assisted reproduction techniques. In this proposal his collaboration will be aimed at developing models of analysis of the follicular environment (niche) that results in epigenetic gamete specific modifications. This is a fundamental science issue, and has the potential to be applied in the medium term to improve the production rates of embryos derived from OPU / IVF and or gametes derived from in vitro production. (AU)

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