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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genomic monitoring unveil the early detection of the SARS-CoV-2 B.1.351 (beta) variant (20H/501Y.V2) in Brazil

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Slavov, Svetoslav N. [1] ; Patane, Jose S. L. [2] ; Bezerra, Rafael dos Santos [1] ; Giovanetti, Marta [3, 4] ; Fonseca, Vagner [3, 5, 6] ; Martins, Antonio J. [2] ; Viala, Vincent L. [2] ; Rodrigues, Evandra S. [1] ; Santos, Elaine V. [1] ; Barros, Claudia R. S. [2] ; Marqueze, Elaine C. [2] ; Santos, Bibiana ; Aburjaile, Flavia [3] ; Neto, Raul M. [2] ; Moretti, Debora B. [2] ; Haddad, Ricardo [2] ; Calado, Rodrigo T. [7, 1] ; Kitajima, Joao P. [8] ; Freitas, Erika [8] ; Schlesinger, David [8] ; Junior de Alcantara, Luiz C. [3, 4] ; Elias, Maria C. [2] ; Sampaio, Sandra C. [2] ; Kashima, Simone [1] ; Covas, Dimas T. [7, 2, 1]
Total Authors: 25
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Blood Ctr Ribeirao Preto, Sao Paulo - Brazil
[2] Butantan Inst, Sao Paulo - Brazil
[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Belo Horizonte, MG - Brazil
[4] Fiocruz MS, Inst Oswaldo Cruz, Rio De Janeiro - Brazil
[5] Minist Saude, CGLAB SVS MS, Coordenacao Geral Lab Saude Publ, Secretaria Vigilancia Saude, Brasilia, DF - Brazil
[6] Univ KwaZulu Natal, KwaZulu Natal Res Innovat & Sequencing Platform K, Durban - South Africa
[7] Univ Sao Paulo, Fac Med Ribeirao Preto, Sao Paulo - Brazil
[8] Mendel Analise Genom SA, Sao Paulo - Brazil
Total Affiliations: 8
Document type: Journal article
Source: Journal of Medical Virology; v. 93, n. 12 JUL 2021.
Web of Science Citations: 4
Abstract

Sao Paulo State, currently experiences a second COVID-19 wave overwhelming the healthcare system. Due to the paucity of SARS-CoV-2 complete genome sequencing, we established a Network for Pandemic Alert of Emerging SARS-CoV-2 Variants to rapidly understand and monitor the spread of SARS-CoV-2 variants into the state. Through analysis of 210 SARS-CoV-2 complete genomes obtained from the largest regional health departments we identified cocirculation of multiple SARS-CoV-2 lineages such as B.1.1 (0.5%), B.1.1.28 (23.2%), B.1.1.7 (alpha variant, 6.2%), B.1.566 (1.4%), B.1.544 (0.5%), C.37 (0.5%) P.1 (gamma variant, 66.2%), and P.2 (zeta variant, 1.0%). Our analysis allowed also the detection, for the first time in Brazil, the South African B.1.351 (beta) variant of concern, B.1.351 (501Y.V2) (0.5%), characterized by the following mutations: ORF1ab: T265I, R724K, S1612L, K1655N, K3353R, SGF 3675\_F3677del, P4715L, E5585D; spike: D80A, D215G, L242\_L244del, A262D, K417N, E484K, N501Y, D614G, A701V, C1247F; ORF3a: Q57H, S171L, E: P71L; ORF7b: Y10F, N: T205I; ORF14: L52F. The most recent common ancestor of the identified strain was inferred to be mid-October to late December 2020. Our analysis demonstrated the P.1 lineage predominance and allowed the early detection of the South African strain for the first time in Brazil. We highlight the importance of SARS-CoV-2 active monitoring to ensure the rapid detection of potential variants for pandemic control and vaccination strategies. (AU)

FAPESP's process: 20/10127-1 - Development of vaccine against COVID-19
Grantee:Dimas Tadeu Covas
Support Opportunities: Research Grants - Research in Public Policies
FAPESP's process: 18/15826-5 - Evaluation of the impact of emerging and reemerging viruses in the field of hemotherapy and stem-cell transplantation by multiple-research approach
Grantee:Svetoslav Nanev Slavov
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
Grantee:Dimas Tadeu Covas
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 20/05367-3 - Convalescent donor plasma to treat patients with severe SARS-CoV-2 infection (COVID-19)
Grantee:Rodrigo do Tocantins Calado de Saloma Rodrigues
Support Opportunities: Regular Research Grants
FAPESP's process: 20/00694-6 - How DNA replication contributes for the success of infection caused by Trypanosoma cruzi
Grantee:Maria Carolina Quartim Barbosa Elias Sabbaga
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/26950-6 - RED BLOOD CELL ALLOIMMUNIZATION IN SICKLE CELL DISEASE: IDENTIFICATION OF RH VARIANTS AND IMMUNE MARKERS
Grantee:Evandra Strazza Rodrigues Sandoval
Support Opportunities: Scholarships in Brazil - Post-Doctoral