Development of vaccine against COVID-19

• Grant number: 20/10127-1
• Support Opportunities: Research Grants - Research in Public Policies
• Duration: September 01, 2020 - February 28, 2023
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Dimas Tadeu Covas
• Grantee: Dimas Tadeu Covas
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Cristiano Gonçalves Pereira ; Débora Botéquio Moretti ; Esper Georges Kallás ; Raul Machado Neto ; Ricardo Palacios Gomez ; Rui Curi

Abstract

After months of the worldwide spread of the SARS-CoV-2 novel coronavirus, it has become clear that the development and manufacturing of a safe and effective vaccine is a promising public policy strategy to combat the pandemic that will allow for the complete reopening of the economy and the prevention of new epidemic waves. Instituto Butantan is a century-old institution dedicated to the development of biological medicines and is responsible for providing 65% of all vaccines and 100% of antivenoms to the public health system in Brazil. Considering the Institute's standing, sustainability and ability to rapidly respond to specific health challenges of the population, it has attracted partnerships with the main developers of immunobiologicals in the world for the development and manufacturing of vaccine candidates for COVID-19. The agreement signed between Instituto Butantan and Sinovac Biotech Ltd to carry out a Phase III clinical trial and subsequent manufacturing of the vaccine developed by the Chinese company is relevant due to the effectiveness demonstrated by the inactivated vaccine in the Phase I and II trials and because it is a traditional and widely used technology. FAPESP, has a recognized role in the production of knowledge and new technologies and is fundamental in the search of solutions to urgent issues. The relationship that will be established between Instituto Butantan and FAPESP to support activities involving the development and licensing of the inactivated vaccine against COVID-19 gears towards the establishing of pandemic control and mitigation policies that impact the health and social and economic conditions of the country. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA, ALEX RANIERI JERONIMO; RIBEIRO, GABRIELA; VIALA, VINCENT LOUIS; DE LIMA, LOYZE PAOLA OLIVEIRA; MARTINS, ANTONIO JORGE; BARROS, CLAUDIA RENATA DOS SANTOS; MARQUEZE, ELAINE CRISTINA; BERNARDINO, JARDELINA DE SOUZA TODAO; MORETTI, DEBORA BOTEQUIO; RODRIGUES, EVANDRA STRAZZA; et al. SARS-COV-2 genomic monitoring in the state of Sao Paulo unveils two emerging AY.43 sublineages. Journal of Medical Virology, v. 94, n. 7, p. 5-pg., 2022-03-12. (20/10127-1)

LESBON, JESSIKA CRISTINA CHAGAS; POLETI, MIRELE DAIANA; DE MATTOS OLIVEIRA, ELISANGELA CHICARONI; PATANE, JOSE SALVATORE LEISTER; CLEMENTE, LUAN GASPAR; VIALA, VINCENT LOUIS; RIBEIRO, GABRIELA; GIOVANETTI, MARTA; DE ALCANTARA, LUIZ CARLOS JUNIOR; DE LIMA, LOYZE PAOLA OLIVEIRA; et al. Nucleocapsid (N) Gene Mutations of SARS-CoV-2 Can Affect Real-Time RT-PCR Diagnostic and Impact False-Negative Results. Viruses-Basel, v. 13, n. 12, DEC 2021. (20/10127-1, 13/08135-2, 20/05367-3)

SLAVOV, SVETOSLAV N.; PATANE, JOSE S. L.; BEZERRA, RAFAEL DOS SANTOS; GIOVANETTI, MARTA; FONSECA, VAGNER; MARTINS, ANTONIO J.; VIALA, VINCENT L.; RODRIGUES, EVANDRA S.; SANTOS, ELAINE V.; BARROS, CLAUDIA R. S.; et al. Genomic monitoring unveil the early detection of the SARS-CoV-2 B.1.351 (beta) variant (20H/501Y.V2) in Brazil. Journal of Medical Virology, v. 93, n. 12, JUL 2021. (20/10127-1, 18/15826-5, 13/08135-2, 20/05367-3, 20/00694-6, 17/26950-6)

PALACIOS, RICARDO; PATINO, ELIZABETH GONZALEZ; DE OLIVEIRA PIORELLI, ROBERTA; CONDE, MONICA TILLI REIS PESSOA; BATISTA, ANA PAULA; ZENG, GANG; XIN, QIANQIAN; KALLAS, ESPER G.; FLORES, JORGE; OCKENHOUSE, CHRISTIAN F.; et al. Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac - PROFISCOV: A structured summary of a study protocol for a randomised controlled trial. Trials, v. 21, n. 1, p. 3-pg., 2020-10-15. (20/10127-1)

VIALA, VINCENT LOUIS; SLAVOV, SVETOSLAV NANEV; OLIVEIRA DE LIMA, LOYZE PAOLA; JERONIMO LIMA, ALEX RANIERI; RIBEIRO, GABRIELA; MARTINS, ANTONIO JORGE; PETRY, BRUNA; BANHO, CECILIA ARTICO; DOS SANTOS BARROS, CLAUDIA RENATA; MONCAU, CRISTINA TSCHORNY; et al. The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela. Viruses-Basel, v. 14, n. 7, p. 9-pg., 2022-07-01. (20/10127-1, 20/06441-2, 18/15826-5)

GIOVANETTI, MARTA; SLAVOV, SVETOSLAV NANEV; FONSECA, VAGNER; WILKINSON, EDUAN; TEGALLY, HOURIIYAH; LEISTER PATANE, JOSE SALVATORE; VIALA, VINCENT LOUIS; SAN, EMMANUEL JAMES; RODRIGUES, EVANDRA STRAZZA; SANTOS, ELAINE VIEIRA; et al. Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil. NATURE MICROBIOLOGY, v. 7, n. 9, p. 14-pg., 2022-08-18. (13/08135-2, 20/10127-1, 20/04836-0, 20/05367-3)

SLAVOV, SVETOSLAV NANEV; LIMA DE LA-ROQUE, DEBORA GLENDA; MENDES DA COSTA, PERICLES NATAN; RODRIGUES, EVANDRA STRAZZA; SANTOS, ELAINE VIEIRA; BORGES, JOSIANE SERRANO; EVARISTO, MARIANE; MACONETTO, JULIANA DE MATOS; MARQUES, ADRIANA APARECIDA; MILHOMENS, JONATHAN; et al. Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil. Viruses-Basel, v. 14, n. 10, p. 12-pg., 2022-10-01. (14/50947-7, 18/15826-5, 20/10127-1, 20/06441-2, 19/22155-2, 17/26950-6, 21/11944-6, 13/08135-2)

ELIAS, MARIA CAROLINA; SLAVOV, SVETOSLAV NANEV; LIMA, ALEX RANIERI JERONIMO; MARTINS, ANTONIO JORGE; BARROS, CLAUDIA RENATA DOS SANTOS; MORETTI, DEBORA BOTEQUIO; ARAUJO, EDUARDO L.; MARQUEZE, ELAINE CRISTINA; RIBEIRO, GABRIELA; RIBEIRO, GABRIELA MAURIC FROSSARD; et al. A traveling SARS-CoV-2 laboratory as part of a pandemic response among vulnerable Brazilian populations. BMC PUBLIC HEALTH, v. 23, n. 1, p. 9-pg., 2023-01-03. (20/10127-1, 20/00694-6, 18/15826-5, 13/07467-1)

COSTA, PRISCILLA RAMOS; CORREIA, CAROLINA ARGONDIZO; MARMORATO, MARIANA PRADO; DE CARVALHO DIAS, JULIANA ZANATTA; THOMAZELLA, MATEUS VAILANT; DA SILVA, AMANDA CABRAL; SOARES DE OLIVEIRA, ANA CAROLINA; GUSMAO, ARIANNE FAGOTTI; FERRARI, LILIAN; FREITAS, ANGELA CARVALHO; et al. Humoral and cellular immune responses to CoronaVac up to one year after vaccination. FRONTIERS IN IMMUNOLOGY, v. 13, p. 15-pg., 2022-10-21. (20/10127-1, 20/06409-1)