Study of transcription factors and their relation with thyroid nodules
| Full text | |
| Author(s): |
Melo, Daniel Hardy
[1]
;
Martins Mamede, Rui Celso
[2]
;
Neder, Luciano
[3]
;
Silva, Jr., Wilson Araujo
[4]
;
Barros-Filho, Mateus Camargo
[5]
;
Kowalski, Luiz Paulo
[5]
;
Lopes Pinto, Clovis Antonio
[6]
;
Zago, Marco Antonio
[7]
;
Alves Figueiredo, David Livingstone
[8]
;
Jungbluth, Achim A.
[9]
Total Authors: 10
|
| Affiliation: | [1] Univ Fed Ceara, Sch Med, 100 Comandante Maurocelio Rocha Pontes Ave, BR-62042280 Sobral - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Ctr Cell Based Therapy, CEPID, FAPESP, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Clin Pathol, Ctr Cell Based Therapy, CEPID, FAPESP, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, Ctr Cell Based Therapy, CEPID, FAPESP, BR-14049900 Ribeirao Preto, SP - Brazil
[5] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509010 Sao Paulo, SP - Brazil
[6] AC Camargo Canc Ctr, Dept Anat Pathol, BR-01509010 Sao Paulo, SP - Brazil
[7] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Ribeirao Preto, SP - Brazil
[8] Midwestern State Univ, UNICTR, Dept Pharm, BR-85040080 Guarapuava, PR - Brazil
[9] Mem Sloan Kettering Canc Ctr, Div Pathol Diagnost Serv, Cytol, 1275 York Ave, New York, NY 10021 - USA
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Oncology Letters; v. 14, n. 6, p. 6485-6496, DEC 2017. |
| Web of Science Citations: | 0 |
| Abstract | |
Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. The expression levels of melanoma-associated antigen (MAGE) A, MAGE-C1/CT7, cancer/testis antigen 1B (CTAG1B) and G antigen (GAGE) were analyzed by immunohistochemistry. None of the CT antigens were expressed in the normal thyroid or goiter. In papillary and follicular carcinoma, MAGE-A was present in 8.1% of cases, GAGE in 10.8% and CT/7MAGE-C1 and CTAG1B in 2.7% each. In medullary carcinoma, CT antigen expression was as follows: MAGE-A in 42.9% of patients; MAGE-C1/CT7 in 46.5%; GAGE in 92.9%; and CTAG1B in 3.6%. A statistically significant association was observed between the expression of G MAGE-C1/CT7 and patient gender as well as patient clinical stage (P=0.029 and 0.031, respectively). (AU) | |
| FAPESP's process: | 13/08135-2 - CTC - Center for Cell-Based Therapy |
| Grantee: | Dimas Tadeu Covas |
| Support type: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |