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Analysis of gene pathways regulated by the HOXB2 gene in glioblastoma

Grant number: 17/24027-6
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2018
Effective date (End): December 31, 2020
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Wilson Araújo da Silva Junior
Grantee:Natália Volgarine Scaraboto Bonfa
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/08135-2 - CTC - Center for Cell-Based Therapy, AP.CEPID
Associated scholarship(s):19/17348-6 - Identification of HOXB2 gene targets in glioblastoma cell line by promotor capture Hi-C technique, BE.EP.MS

Abstract

HOX genes are a subgroup of the Homeobox family characterized by high degree of conservation among fungi, plants and animals. In mammals, there are 39 HOX genes distributed in four groups or clusters: HOXA, HOXB, HOXC and HOXD, located on chromosomes 2, 7, 17 and 12, respectively. HOX genes are transcription factors that act during embryonic development, regulating fundamental biological processes such as: proliferation, differentiation, migration, angiogenesis and apoptosis. Recent studies have indicated a tissue-specific expression profile of HOX genes in different tumor types, suggesting an important role in tumorigenesis. Previous analyses performed by our group demonstrated that 33 HOX genes are hyperexpressed in glioblastoma (GBM), which is considered the most aggressive tumor of the central nervous system. In addition, analysed data from public platforms indicated that patients with GBM and with high expression of HOXB2 have low survival. In this context, our main objective will be to evaluate, based on the information of its targets, the functional role of the HOXB2 gene in glioblastoma. (AU)