Baroreflex stimulation attenuates central but not peripheral inflammation in conscious endotoxemic rats

Autor(es)

Brognara, Fernanda ^[1] ; Castania, Jaci A. ^[1] ; Dias, Daniel P. M. ^[1] ; Lopes, Alexandre H. ^[2] ; Fazan, Jr., Rubens ^[1] ; Kanashiro, Alexandre ^[3] ; Ulloa, Luis ^[4] ; Salgado, Helio C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP - Brazil

^[3] Univ Fed Sao Carlos, Dept Physiol Sci, Sao Carlos, SP - Brazil

^[4] Rutgers State Univ, Dept Surg, Ctr Immunol & Inflammat, New Jersey Med Sch, Newark, NJ 07103 - USA

• Tipo de documento: Artigo Científico
• Fonte: Brain Research; v. 1682, p. 54-60, MAR 1 2018.
• Citações Web of Science: 4

Resumo

We previously reported that activation of the baroreflex, a critical physiological mechanism controlling cardiovascular homeostasis, through electrical stimulation of the aortic depressor nerve attenuates joint inflammation in experimental arthritis. However, it is unknown whether baroreflex activation can control systemic inflammation. Here, we investigate whether baroreflex activation controls systemic inflammation in conscious endotoxemic rats. Animals underwent sham or electrical aortic depressor nerve stimulation initiated 10 min prior to a lipopolysaccharide (LPS) challenge, while inflammatory cytokine levels were measured in the blood, spleen, heart and hypothalamus 90 min after LPS treatment. Baroreflex activation did not affect LPS-induced levels of pro-inflammatory (tumor necrosis factor, interleukin 1 beta and interleukin 6) or anti-inflammatory (interleukin 10) cytokines in the periphery (heart, spleen and blood). However, baroreflex stimulation attenuated LPS-induced levels of all these cytokines in the hypothalamus. Notably, these results indicate that the central anti-inflammatory mechanism induced by baroreflex stimulation is independent of cardiovascular alterations, since aortic depressor nerve stimulation that failed to induce hemodynamic changes was also efficient at inhibiting inflammatory cytokines in the hypothalamus. Thus, aortic depressor nerve stimulation might represent a novel therapeutic strategy for neuroprotection, modulating inflammation in the central nervous system. (C) 2018 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 14/15386-4 - Modulação da resposta inflamatória ao LPS pela ativação elétrica do barorreflexo em ratos acordados
• Beneficiário: Fernanda Brognara Penteado Dias
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 11/20343-4 - Via colinérgica anti-inflamatória: o papel da neuroimunomodulação no controle da resposta inflamatória
• Beneficiário: Alexandre Kanashiro
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 13/20549-7 - Avanços na regulação cardiocirculatória em condições fisiológica e fisiopatológica
• Beneficiário: Helio Cesar Salgado
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/05163-6 - Papel do sistema nervoso autônomo parassimpático e simpático na modulação da sepse em ratos não anestesiados
• Beneficiário: Fernanda Brognara Penteado Dias
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto