Evaluation of Prolonged Exposure to Varenicline in Adult Rats: Haematological, Biochemical and Anatomopathological Studies

Autor(es)

Zaccarelli-Magalhaes, Julia ^[1] ; Moreira, Natalia ^[1] ; Sandini, Thaisa Meira ^[2] ; de Abreu, Gabriel Ramos ^[3] ; Sanchez-Sarmiento, Angelica Maria ^[1] ; Ricci, Esther Lopes ^[3] ; Fukushima, Andre Rinaldi ^[4] ; Spinosa, Helenice de Souza ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pathol, Sch Vet Med & Anim Sci, Ave Prof Dr Orlando Marques Paiva 87, BR-05508270 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci, Sao Paulo - Brazil

^[3] Presbiterian Mackenzie Univ, Hlth Sci Inst, Sao Paulo - Brazil

^[4] Univ Sao Judas Tadeu, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY; v. 122, n. 3, p. 305-309, MAR 2018.
• Citações Web of Science: 2

Resumo

Varenicline is a synthetic chemical substance produced from the alkaloid cytisine, used for smoking treatment, which acts as a partial agonist for 42 and 34 nicotinic cholinergic receptors and as a total agonist for 7 receptor. While there are studies regarding varenicline's non-smoking-related effects, as in treatment for drug dependence, there are no studies in the literature evaluating the long-term toxicity of varenicline through a physiological approach. Thus, the aim of this study was to evaluate possible toxicity through haematological, biochemical and anatomopathological parameters of prolonged exposure (30days) to varenicline in rats. Three doses of varenicline were used: 0.03 (therapeutic dose for human beings), 0.1 and 0.3mg/kg orally (gavage). Body-weight, water and food intake were measured weekly during treatment. On the 30th treatment day, blood and various organs were collected for haematological, biochemical and anatomopathological evaluations. The results show a decrease in some biochemical parameters in animals from the 0.1 and 0.3mg/kg group, although the values are within the normal range of the species. There were no changes in the other evaluations performed. Together, these data indicate that prolonged exposure of rats to different doses of varenicline was not able to alter haematological, biochemical and anatomopathological parameters. (AU)

• Processo FAPESP: 15/05049-3 - Exposição prolongada de ratos a vareniclina: avaliações comportamental, de neurotransmissores cerebrais, bioquímica e anatomopatológica
• Beneficiário: Julia Zaccarelli Magalhães
• Modalidade de apoio: Bolsas no Brasil - Mestrado