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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Diet-induced glucose homeostasis dysregulation is enhanced by taurine supplementation in ovariectomized mice

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Autor(es):
Santos, Roberta de Souza [1, 2] ; Camargo, Rafael L. [1, 2] ; Vanzela, Emerielle C. [1] ; Batista, Thiago M. [1] ; Morato, Priscila N. [1] ; Leite, Nayara C. [1] ; Rovani, Juliana C. [1] ; Garcia-Arevalo, Marta [1] ; Clegg, Deborah J. [2] ; Carneiro, Everardo M. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Inst Biol, OCRC, Campinas, SP - Brazil
[2] Cedars Sinai Med Ctr, Diabet & Obes Res Div, Biomed Res Dept, 8700 Beverly Blvd, Los Angeles, CA 90048 - USA
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Amino Acids; v. 50, n. 3-4, p. 469-477, APR 2018.
Citações Web of Science: 1
Resumo

Low levels of estrogens are associated with obesity-related comorbidities. Mice with lower levels of estrogens are thereby more sensitive to the effects of a high-fat-diet (HFD) for the development of glucose intolerance and insulin resistance. Studies in vivo have demonstrated that taurine (TAU) supplementation prevents glucose and insulin resistance. Thus, we aimed to investigate the potential beneficial effects of TAU supplementation on glucose homeostasis of mice with low levels of estrogens fed with a HFD. 3-month-old female C57BL/6J mice underwent bilateral ovariectomy (OVX). After 1 week of recovery, mice were divided into 4 groups and either received: a standard chow diet (OVXC), chow diet plus drinking water enriched with 3% of TAU (OVXCT), HFD (OVXH), and HFD plus supplementation of TAU (OVXHT) for 14 weeks. Exposure to the HFD increased adiposity and plasma levels of glucose and insulin. Contrary to our prediction, the addition of TAU enhanced the deleterious effects of the HFD. Glucose and insulin tolerance tests (ipGTT and ipITT) indicated that mice maintained on the HFD + TAU had worse glucose intolerance and insulin resistance that was linked to lower insulin signaling in skeletal muscle and liver. Insulin secretion of isolated pancreatic islets of OVXH mice was higher than OVXC, and the addition of TAU associated with a HFD did not modulate insulin secretion, suggesting a failure of pancreatic beta cells of OVXHT mice. These results suggest that despite the beneficial reports of TAU, it should be used cautiously in situations where the levels of estrogens are low. (AU)

Processo FAPESP: 12/50430-9 - Caracterização molecular e funcional da secreção e ação da insulina em camundongos fêmeas obesas menopausadas e suplementadas com taurina
Beneficiário:Roberta de Souza Santos
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
Beneficiário:Licio Augusto Velloso
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs