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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Previous exposure to chronic intermittent hypoxia blunts the development of one-kidney, one-clip hypertension in rats

Texto completo
Autor(es):
Perim, Raphael R. [1] ; Amorim, Mateus R. [1] ; Bonagamba, The Late Leni G. H. [1] ; Machado, Benedito H. [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Experimental Physiology; v. 103, n. 4, p. 473-482, APR 1 2018.
Citações Web of Science: 4
Resumo

Chronic intermittent hypoxia (CIH) and one-kidney, one-clip (1K, 1C) experimental models lead to sympathetic overactivity and hypertension. We hypothesized that previous exposure to CIH potentiates the development of 1K, 1C renal hypertension. Male rats were divided into the following four groups: Control-1K, 1C, maintained under normoxia followed by 1K, 1C surgery (n=19); Control-Sham, maintained under normoxia, followed by sham surgery (n=19); CIH-1K, 1C, exposed to CIH (10days) and 1K, 1C surgery (n=19); and CIH-Sham, exposed to CIH and sham surgery (n=18). Animals were catheterized 8days after 1K, 1C or Sham surgeries and cardiovascular and respiratory parameters recorded on the following day. Baseline mean arterial pressure was higher in Control-1K, 1C than in Control-Sham rats (P<0.05) and was higher in CIH-1K, 1C than in CIH-Sham rats (P<0.05). However, the increase in mean arterial pressure in CIH-1K, 1C animals was significantly blunted in comparison to Con-1K, 1C rats (P<0.05), indicating that previous exposure to CIH attenuates the development of renal hypertension. Systemic administration of hexamethonium, a ganglionic blocker, promoted a larger hypotensive response in Con-1K, 1C compared with CIH-1K, 1C rats (P<0.05), suggesting that sympathetic activity was attenuated in rats previously exposed to the CIH protocol. In addition, removal of the carotid bodies before 1K, 1C renal hypertension eliminated the protective effect of CIH preconditioning on the development of the 1K, 1C hypertension. We conclude that previous exposure to CIH attenuates the development of renal hypertension via a carotid body-dependent mechanism. (AU)

Processo FAPESP: 13/06077-5 - Alterações nas redes neurais envolvidas na geração e controle das atividades simpática e respiratória em diferentes modelos experimentais de hipóxia
Beneficiário:Benedito Honorio Machado
Linha de fomento: Auxílio à Pesquisa - Temático