An overview of the immune modulating effects of enzymatic toxins from snake venoms

Autor(es)

Burin, Sandra M. ^[1] ; Menaldo, Danilo L. ^[1] ; Sampaio, Suely V. ^[1] ; Frantz, Fabiani G. ^[1] ; Castro, Fabiola A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: International Journal of Biological Macromolecules; v. 109, p. 664-671, APR 2018.
• Citações Web of Science: 2

Resumo

Snake venoms are complex mixtures of organic and inorganic compounds, including proteins belonging to the protease (serine and metalloproteinases), oxidase (L-amino acid oxidases), and phospholipase (especially phospholipases A(2)) enzyme classes. These toxins account for the serious deleterious effects of snake envenomations, such as tissue necrosis, neurotoxicity, and hemorrhage. In addition to their toxic effects, snake venom toxins have served as important tools for investigating the mechanisms underlying envenomation and discovering new pharmacologically active compounds with immunotherapeutic potential. In this sense, the present review discusses the new findings and therapeutic perspectives in the immune modulating potential of enzymatic toxins from snake venoms belonging to the classes metalloproteinase, serine protease, L-amino acid oxidase, and phospholip'ase A(2). (C) 2017 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/23236-4 - Toxinas animais nativas e recombinantes: análise funcional, estrutural e molecular
• Beneficiário: Suely Vilela
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/25637-7 - Modulação epigenética da maquinaria apoptótica em células Bcr-Abl positivas pelas toxinas BmooLAAO-I e MjTX-I
• Beneficiário: Sandra Mara Burin de Menezes
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado