Modulating effect of low intensity pulsed ultrasound on the phenotype of inflammatory cells

Autor(es)

da Silva Junior, Evaldo Moreira ^{[1, 2]} ; Mesquita-Ferrari, Raquel Agnelli ^{[1, 2]} ; Franca, Cristiane Miranda ^[1] ; Andreo, Lucas ^{[1, 2]} ; Bussadori, Sandra Kalil ^{[1, 2]} ; Santos Fernandes, Kristianne Porta ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, 249 Vergueiro St, BR-01504001 Sao Paulo, SP - Brazil

^[2] Univ Nove Julho UNINOVE, Postgrad Program Rehabil Sci, 249 Vergueiro St, BR-0150400 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOMEDICINE & PHARMACOTHERAPY; v. 96, p. 1147-1153, DEC 2017.
• Citações Web of Science: 2

Resumo

Aims: The purpose of this study was toclarify the effect of low intensity pulsed ultrasound (LIPUS) on the phenotype of the inflammatory infiltrate in muscle tissue following acute injury. Main methods: Forty Wistar rats were submitted to cryoinjury of the tibialis anterior muscle and only half were treated with LIPUS. After 1, 2, 3 and 7 days macrophages and neutrophils were quantified. Key findings: With one day, LIPUS led to reductions in the number of neutrophils and M1 macrophages. After two days, muscles treated with LIPUS had fewer total macrophages and M1 macrophages, but a greater number of M2 macrophages. Muscles treated with LIPUS showed fewer macrophages after three and seven days. Significance: As the permanence of cells with pro-inflammatory and anti-inflammatory action can lead to the perpetuation of inflammation with consequent tissue damage and tissue fibrosis, respectively, the ability of LIPUS to modulate the occurrence of these cells demonstrates the therapeutic potential of this resource. (AU)

• Processo FAPESP: 14/12381-1 - Análise comparativa do efeito da laserterapia prévia associada ou não ao tratamento pós sobre a modulação de citocinas inflamatórias, do estresse oxidativo e a determinação do tipo de fibra muscular após lesão aguda
• Beneficiário: Raquel Agnelli Mesquita Ferrari
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07502-1 - Efeito da laserterapia sobre a expressão gênica e a produção de citocinas, quimiocinas e fatores de crescimento envolvidos no reparo muscular
• Beneficiário: Kristianne Porta Santos Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Regular