Possible Breathing Influences on the Control of Arterial Pressure After Sino-aortic Denervation in Rats

Autor(es)

Amorim, Mateus R. ^[1] ; Souza, George Miguel P. R. ^[1] ; Machado, Benedito H. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT HYPERTENSION REPORTS; v. 20, n. 1 JAN 2018.
• Citações Web of Science: 1

Resumo

Purpose of Review Surgical removal of the baroreceptor afferents {[}sino-aortic denervation (SAD)] leads to a lack of inhibitory feedback to sympathetic outflow, which in turn is expected to result in a large increase in mean arterial pressure (MAP). However, few days after surgery, the sympathetic nerve activity (SNA) and MAP of SAD rats return to a range similar to that observed in control rats. In this review, we present experimental evidence suggesting that breathing contributes to control of SNA and MAP following SAD. The purpose of this review was to discuss studies exploring SNA and MAP regulation in SAD rats, highlighting the possible role of breathing in the neural mechanisms of this modulation of SNA. Recent Findings Recent studies show that baroreceptor afferent stimulation or removal (SAD) results in changes in the respiratory pattern. Summary Changes in the neural respiratory network and in the respiratory pattern must be considered among mechanisms involved in the modulation of the MAP after SAD. (AU)

• Processo FAPESP: 13/06077-5 - Alterações nas redes neurais envolvidas na geração e controle das atividades simpática e respiratória em diferentes modelos experimentais de hipóxia
• Beneficiário: Benedito Honorio Machado
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/15195-1 - Caracterização eletrofisiológica dos neurônios respiratórios e pré-simpáticos da região rostral ventrolateral do bulbo após a desnervação sino-aórtica em ratos
• Beneficiário: Mateus Ramos Amorim
• Modalidade de apoio: Bolsas no Brasil - Doutorado