Possible Breathing Influences on the Control of Arterial Pressure After Sino-aortic Denervation in Rats

Author(s)

Amorim, Mateus R. ^[1] ; Souza, George Miguel P. R. ^[1] ; Machado, Benedito H. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil

• Document type: Review article
• Source: CURRENT HYPERTENSION REPORTS; v. 20, n. 1 JAN 2018.
• Web of Science Citations: 1

Abstract

Purpose of Review Surgical removal of the baroreceptor afferents {[}sino-aortic denervation (SAD)] leads to a lack of inhibitory feedback to sympathetic outflow, which in turn is expected to result in a large increase in mean arterial pressure (MAP). However, few days after surgery, the sympathetic nerve activity (SNA) and MAP of SAD rats return to a range similar to that observed in control rats. In this review, we present experimental evidence suggesting that breathing contributes to control of SNA and MAP following SAD. The purpose of this review was to discuss studies exploring SNA and MAP regulation in SAD rats, highlighting the possible role of breathing in the neural mechanisms of this modulation of SNA. Recent Findings Recent studies show that baroreceptor afferent stimulation or removal (SAD) results in changes in the respiratory pattern. Summary Changes in the neural respiratory network and in the respiratory pattern must be considered among mechanisms involved in the modulation of the MAP after SAD. (AU)

• FAPESP's process: 13/06077-5 - Changes in the neural networks involved with the generation and control of sympathetic and respiratory activities in different experimental models of hypoxia
• Grantee: Benedito Honorio Machado
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/15195-1 - Electrophysiological characterization of respiratory and presympathetic neurons in the rostral ventrolateral medulla after sinoaortic denervation in rats
• Grantee: Mateus Ramos Amorim
• Support Opportunities: Scholarships in Brazil - Doctorate