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Role of baroreflex in the time course of autonomic and metabolic alterations of fructose-overload hypertension

Grant number: 13/23418-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): February 01, 2014
Effective date (End): January 31, 2016
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Maria Claudia Costa Irigoyen
Grantee:Fernando dos Santos
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


The increase of fructose consumption in recent decades is closely associated with a higher incidence of comorbidities such as obesity, dysautonomia and development of metabolic syndrome. However, the literature does not have an accurate characterization of events occurring during the development of these comorbidities. Base on these information, this paper aims to assess temporal changes in autonomic and metabolic parameters in a model of metabolic syndrome induced by fructose overload, with focus on the role of baroreflex, as evaluated by sinoaortic denervation. We used four experimental groups of animals (rats), followed by 90 days: control (C), denervated control (D), treated with fructose (F) and denervated treated with fructose (DF). The treated groups were submitted to a fructose overload (10%) in drinking water. The evaluation of the cardiovascular and autonomic parameters occurred by recording blood pressure and heart rate via telemetry once a week, 24 hours per day for 13 weeks. The monitoring of metabolic indices started with measurement of food and water consumption, body weight quantification and daily caloric intake, in addition blood glucose tests and insulin tolerance test were performed. Moreover, the animals were allocated in metabolic cage (24 hours each month of the protocol) to measure the urine volume. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, FERNANDO; MORAES-SILVA, IVANA C.; MOREIRA, EDSON D.; IRIGOYEN, MARIA-CLAUDIA. The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations. SCIENTIFIC REPORTS, v. 8, JUL 20 2018. Web of Science Citations: 2.

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