Silver(I) and zinc(II) complexes with symmetrical cinnamaldehyde Schiff base derivative: Spectroscopic, powder diffraction characterization, and antimycobacterial studies

Autor(es)

Amaral, Thaeny C. ^[1] ; Miguel, Fabio B. ^[2] ; Couri, Mara R. C. ^[2] ; Corbi, Pedro P. ^[3] ; Carvalho, Marcos A. ^[3] ; Campos, Debora L. ^[4] ; Pavan, Fernando R. ^[4] ; Cuin, Alexandre ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Juiz de Fora, Dept Quim, Lab Quim BioInorgan, LQBin, Inst Ciencias Exatas, BR-36036330 Juiz de Fora, MG - Brazil

^[2] Univ Fed Juiz de Fora, Inst Ciencias Exatas, Dept Quim, BR-36036330 Juiz De Fora, MG - Brazil

^[3] Univ Estadual Campinas, UNICAMP, Inst Quim, BR-13083970 Campinas, SP - Brazil

^[4] UNESP, Dept Ciencias Biol, Lab Pesquisas TB, Fac Ciencias Farmaceut, BR-14801903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Polyhedron; v. 146, p. 166-171, MAY 15 2018.
• Citações Web of Science: 2

Resumo

Silver(I) and zinc(II) complexes with N,N'-bis(trans-cinnamaldehyde)ethane-1,2-diamine (EnCinn) have been synthesized and characterized by elemental analysis, simultaneous thermogravimetric and differential thermal studies (TG-DTA), infrared (IR), H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopic measurements and electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-QTOF-MS). Crystal and molecular structure descriptions were performed based on powder X-ray diffraction data. The AgEnCinn complex has a polymeric structure where the ligand bridges between two Ag(I) ions, while the ZnEnCinn complex has a monomeric structure with EnCinn acting as chelating ligand. Antimycobacterial assays over Mycobacterium tuberculosis showed the activity of the Ag(I) complex with Minimum Inhibitory Concentration (MIC) value of 22.7 mu mol L-1, while the Zn(II) complex was shown to be inactive over the same experimental conditions. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 15/25114-4 - Preparação de novos complexos de Ag(I), Cu(II), Pd(II) e Pt(II) à base de sulfonamidas e derivados: estudos de atividade antibacteriana e perspectivas de aplicação em lesões de pele criticamente colonizadas.
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular