Presence of -Lactamase Encoding Genes in Burkholderia cepacia Complex Isolated from Soil

Autor(es)

Rueda Furlan, Joao Pedro ^[1] ; Sanchez, Danilo Garcia ^[1] ; Fachin, Ana Lucia ^[2] ; Stehling, Eliana Guedes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ave Cafe S-N, BR-14040903 Ribeirao Preto - Brazil

^[2] Univ Ribeirao Preto, Unidade Biotecnol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MICROBIAL DRUG RESISTANCE; v. 24, n. 4, p. 347-352, MAY 2018.
• Citações Web of Science: 0

Resumo

Burkholderia cepacia complex has emerged as an important opportunistic bacteria group for immunocompromised patients, and it has a high level of intrinsic resistance for different antibiotic classes. Hydrolysis of -lactam antibiotics by -lactamases is the most common resistance mechanism in Gram-negative bacteria, and the presence of such enzymes complicates the selection of appropriate therapy. This study aimed at investigating the antimicrobial resistance profile and the presence of -lactamase encoding genes in B. cepacia complex isolated from Brazilian soils. High-level ceftazidime resistance and several -lactamase encoding genes were found, including the first report of bla(KPC) genes in bacteria isolated from soil. (AU)

• Processo FAPESP: 15/18990-2 - Investigação dos mecanismos de resistência às quinolonas em isolados bacterianos ambientais
• Beneficiário: Eliana Guedes Stehling
• Modalidade de apoio: Auxílio à Pesquisa - Regular