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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Signatures of Long-Term Balancing Selection in Human Genomes

Texto completo
Bitarello, Barbara D. [1, 2] ; de Filippo, Cesare [2] ; Teixeira, Joao C. [2, 3] ; Schmidt, Joshua M. [2] ; Kleinert, Philip [2, 4] ; Meyer, Diogo [1] ; Andres, Aida M. [2, 5]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Genet & Evolutionary Biol, Sao Paulo - Brazil
[2] Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, Leipzig - Germany
[3] Inst Pasteur, Unit Human Evolutionary Genet, Paris - France
[4] Max Planck Inst Mol Genet, Computat Mol Biol Dept, Berlin - Germany
[5] UCL, UCL Genet Inst, Dept Genet Evolut & Environm, London - England
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: GENOME BIOLOGY AND EVOLUTION; v. 10, n. 3, p. 939-955, MAR 2018.
Citações Web of Science: 12

Balancing selectionmaintains advantageous diversity in populations through variousmechanisms. Although extensively explored from a theoretical perspective, an empirical understanding of its prevalence and targets lags behind our knowledge of positive selection. Here, we describe the Non-central Deviation (NCD), a simple yet powerful statistic to detect long-term balancing selection (LTBS) that quantifies how close frequencies are to expectations under LTBS, and provides the basis for a neutrality test. NCD can be applied to a single locus or genomic data, and can be implemented considering only polymorphisms (NCD1) or also considering fixed differences with respect to an outgroup (NCD2) species. Incorporating fixed differences improves power, and NCD2 has higher power to detect LTBS in humans under different frequencies of the balanced allele(s) than other available methods. Applied to genome-wide data from African and European human populations, in both cases using chimpanzee as an outgroup, NCD2 shows that, albeit not prevalent, LTBS affects a sizable portion of the genome: similar to 0.6% of analyzed genomic windows and 0.8% of analyzed positions. Significant windows (P< 0.0001) contain 1.6% of SNPs in the genome, which disproportionally fall within exons and change protein sequence, but are not enriched in putatively regulatory sites. These windows overlap similar to 8% of the protein-coding genes, and these have larger number of transcripts than expected by chance even after controlling for gene length. Our catalog includes known targets of LTBS but a majority of them (90%) are novel. As expected, immune-related genes are among thosewith the strongest signatures, althoughmost candidates are involved in other biological functions, suggesting that LTBS potentially influences diverse human phenotypes. (AU)

Processo FAPESP: 12/18010-0 - Seleção balanceadora no genoma humano: detecção, causas e consequências
Beneficiário:Diogo Meyer
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/19563-2 - Detectando genes e regiões genômicas sob seleção balanceadora no Genoma Humano
Beneficiário:Bárbara Domingues Bitarello
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 11/12500-2 - Má-adaptação como subproduto da adaptação: um estudo em escala genômica
Beneficiário:Bárbara Domingues Bitarello
Linha de fomento: Bolsas no Brasil - Doutorado