Assessment of elimination profile of albendazole residues in fish

Autor(es)

Busatto, Zenais ^[1] ; de Franca, Welliton Goncalves ^[2] ; Possebon Cyrino, Jose Eurico ^[2] ; Rizzato Paschoal, Jonas Augusto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Dept Ciencia Anim, Escola Super Agr Luiz de Queiroz, Piracicaba - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure; v. 35, n. 1, p. 77-85, 2018.
• Citações Web of Science: 1

Resumo

Few drugs are specifically regulated for aquaculture. Thus this study considered albendazole (ABZ) as a potential drug for use in fish, which, however, is not yet regulated for this application. ABZ is a broad-spectrum anthelmintic approved for farmed ruminants and recently considered for treatment of fish parasites. It is the subject of careful monitoring because of potential residues in animal products. This study evaluated the depletion of ABZ and its main known metabolites: albendazole sulfoxide - ABZSO, albendazole sulfone - ABZSO(2) and albendazole amino sulfone - ABZ-2-NH2SO2, in the fillets of the Neotropical Characin pacu, Piaractus mesopotamicus, which were fed diets containing 10mg ABZ kg(-1) body weight in a single dose. Fish were euthanised at 8, 12, 24, 48, 72, 96 and 120hours after medication and the depletion profiles of ABZ, each metabolite and the sum of all marker residues were assessed and evaluated taking into account methodological variations regarding determination of the maximum residue limits adopted by different international regulating agencies for estimation of the withdrawal period (WP). The estimated WPs ranged from 2 to 7 days. (AU)

• Processo FAPESP: 12/18334-0 - Resíduos de medicamentos veterinários em alimentos: métodos analíticos multiclasses empregando LC-MS/MS, dados de exposição e estudos de depleção residual
• Beneficiário: Jonas Augusto Rizzato Paschoal
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores