Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease

Autor(es)

Zambrano, Laura M. G. ^[1] ; Brandao, Dayane A. ^[1] ; Rocha, Fernanda R. G. ^[1] ; Marsiglio, Raquel P. ^[1] ; Longo, Ieda B. ^[1] ; Primo, Fernando L. ^[2] ; Tedesco, Antonio C. ^[3] ; Guimaraes-Stabili, Morgana R. ^[1] ; Rossa Junior, Carlos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Sch Dent Araraquara, Dept Diag & Surg, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ, UNESP, Fac Pharmaceut Sci Araraquara, Dept Bioproc & Biotechnol, Araraquara, SP - Brazil

^[3] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Ctr Nanotechnol & Tissue Engn, Dept Chem, Photobiol & Photomed Res Grp, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 8, APR 27 2018.
• Citações Web of Science: 7

Resumo

There is evidence indicating that curcumin has multiple biological activities, including anti-inflammatory properties. In vitro and in vivo studies demonstrate that curcumin may attenuate inflammation and the connective tissue destruction associated with periodontal disease. Most of these studies use systemic administration, and considering the site-specific nature of periodontal disease and also the poor pharmacodynamic properties of curcumin, we conducted this proof of principle study to assess the biological effect of the local administration of curcumin in a nanoparticle vehicle on experimental periodontal disease. We used 16 rats divided into two groups of 8 animals according to the induction of experimental periodontal disease by bilateral injections of LPS or of the vehicle control directly into the gingival tissues 3x/week for 4 weeks. The same volume of curcumin-loaded nanoparticles or of nanoparticle vehicle was injected into the same sites 2x/week. mu CT analysis showed that local administration of curcumin resulted in a complete inhibition of inflammatory bone resorption and in a significant decrease of both osteoclast counts and of the inflammatory infiltrate; as well as a marked attenuation of p38 MAPK and NF-kappa B activation. We conclude that local administration of curcumin-loaded nanoparticles effectively inhibited inflammation and bone resorption associated with experimental periodontal disease. (AU)

• Processo FAPESP: 12/24196-9 - Modulação da imunidade adaptativa por produtos solúveis de células de HNSCC: um papel da galanina derivada do tumor?
• Beneficiário: Carlos Rossa Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular