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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease

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Author(s):
Zambrano, Laura M. G. [1] ; Brandao, Dayane A. [1] ; Rocha, Fernanda R. G. [1] ; Marsiglio, Raquel P. [1] ; Longo, Ieda B. [1] ; Primo, Fernando L. [2] ; Tedesco, Antonio C. [3] ; Guimaraes-Stabili, Morgana R. [1] ; Rossa Junior, Carlos [1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Paulista, UNESP, Sch Dent Araraquara, Dept Diag & Surg, Araraquara, SP - Brazil
[2] Sao Paulo State Univ, UNESP, Fac Pharmaceut Sci Araraquara, Dept Bioproc & Biotechnol, Araraquara, SP - Brazil
[3] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Ctr Nanotechnol & Tissue Engn, Dept Chem, Photobiol & Photomed Res Grp, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, APR 27 2018.
Web of Science Citations: 7
Abstract

There is evidence indicating that curcumin has multiple biological activities, including anti-inflammatory properties. In vitro and in vivo studies demonstrate that curcumin may attenuate inflammation and the connective tissue destruction associated with periodontal disease. Most of these studies use systemic administration, and considering the site-specific nature of periodontal disease and also the poor pharmacodynamic properties of curcumin, we conducted this proof of principle study to assess the biological effect of the local administration of curcumin in a nanoparticle vehicle on experimental periodontal disease. We used 16 rats divided into two groups of 8 animals according to the induction of experimental periodontal disease by bilateral injections of LPS or of the vehicle control directly into the gingival tissues 3x/week for 4 weeks. The same volume of curcumin-loaded nanoparticles or of nanoparticle vehicle was injected into the same sites 2x/week. mu CT analysis showed that local administration of curcumin resulted in a complete inhibition of inflammatory bone resorption and in a significant decrease of both osteoclast counts and of the inflammatory infiltrate; as well as a marked attenuation of p38 MAPK and NF-kappa B activation. We conclude that local administration of curcumin-loaded nanoparticles effectively inhibited inflammation and bone resorption associated with experimental periodontal disease. (AU)

FAPESP's process: 12/24196-9 - Modulation of adaptive immunity by soluble products of HNSCC cells: a role for tumor-derived galanin?
Grantee:Carlos Rossa Junior
Support Opportunities: Regular Research Grants