| Texto completo | |
| Autor(es): Mostrar menos - |
Ciol, Mariana Rosolen
[1]
;
Manzano, Carlos Marrote
[1]
;
Cuin, Alexandre
[2]
;
Pavan, Fernando Rogerio
[3]
;
Ribeiro, Camila Maringolo
[3]
;
Tasca Gois Ruiz, Ana Lucia
[4, 5]
;
de Oliveira, Ellen Cristina S.
[5]
;
Lustri, Wilton Rogerio
[6]
;
Fregonezi, Nathalia Ferreira
[6]
;
Resende Nogueira, Flavia Aparecida
[6]
;
Corbi, Pedro P.
[1]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] Univ Campinas UNICAMP, Dept Inorgan Chem, POB 6154, BR-13083970 Campinas, SP - Brazil
[2] Fed Univ Juiz de Fora UFJF, Bioinorgan Chem Res Lab, BR-36036330 Juiz De Fora, MG - Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP - Brazil
[4] Univ Campinas UNICAMP, Fac Pharmaceut Sci, BR-13083871 Campinas, SP - Brazil
[5] Univ Campinas UNICAMP, Chem Biol & Agr Pluridisciplinary Res Ctr CPQBA, BR-13148218 Paulinia, SP - Brazil
[6] Univ Araraquara UNIARA, Biol & Hlth Sci Dept, BR-14801320 Araraquara, SP - Brazil
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRYSELECT; v. 3, n. 6, p. 1719-1726, FEB 14 2018. |
| Citações Web of Science: | 2 |
| Resumo | |
Synthesis, characterization and biological activities of a silver(I) complex with cycloserine (AgCIC) are presented. Elemental, thermal and mass spectrometric analyses permitted proposing the minimal formula AgC3H5N2O2. The structure of the AgCIC complex was solved by powder X-ray diffraction (XRD) studies. Coordination of the ligand to silver was shown to occur by the nitrogen atom of the heterocyclic ring and by the nitrogen and oxygen atoms of the amino and carbonyl groups, leading to a polymeric arrangement. Infrared (IR) and nuclear magnetic resonance (NMR) spectroscopic analyses confirmed the coordination sites. Antibacterial assays revealed the activity of the AgCIC complex against Mycobacterium tuberculosis, with minimal inhibitory concentration (MIC90) of 79.1 molL(-1), and against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa bacterial strains. Antiproliferative assays over a panel of tumoral and non-tumoral cells showed that the AgCIC complex is more active and selective than doxorubicin against breast and leukemia cancer cells, considering the total growth inhibition (TGI) values. The interaction of the complex with biomolecules and its mutagenicity were also investigated. (AU) | |
| Processo FAPESP: | 15/09833-0 - Dispositivos de liberação sustentada baseados em biocelulose/complexos metálicos com ligantes bioativos |
| Beneficiário: | Wilton Rogério Lustri |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/25114-4 - Preparação de novos complexos de Ag(I), Cu(II), Pd(II) e Pt(II) à base de sulfonamidas e derivados: estudos de atividade antibacteriana e perspectivas de aplicação em lesões de pele criticamente colonizadas. |
| Beneficiário: | Pedro Paulo Corbi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |