| Full text | |
| Author(s): Show less - |
Ciol, Mariana Rosolen
[1]
;
Manzano, Carlos Marrote
[1]
;
Cuin, Alexandre
[2]
;
Pavan, Fernando Rogerio
[3]
;
Ribeiro, Camila Maringolo
[3]
;
Tasca Gois Ruiz, Ana Lucia
[4, 5]
;
de Oliveira, Ellen Cristina S.
[5]
;
Lustri, Wilton Rogerio
[6]
;
Fregonezi, Nathalia Ferreira
[6]
;
Resende Nogueira, Flavia Aparecida
[6]
;
Corbi, Pedro P.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Campinas UNICAMP, Dept Inorgan Chem, POB 6154, BR-13083970 Campinas, SP - Brazil
[2] Fed Univ Juiz de Fora UFJF, Bioinorgan Chem Res Lab, BR-36036330 Juiz De Fora, MG - Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP - Brazil
[4] Univ Campinas UNICAMP, Fac Pharmaceut Sci, BR-13083871 Campinas, SP - Brazil
[5] Univ Campinas UNICAMP, Chem Biol & Agr Pluridisciplinary Res Ctr CPQBA, BR-13148218 Paulinia, SP - Brazil
[6] Univ Araraquara UNIARA, Biol & Hlth Sci Dept, BR-14801320 Araraquara, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | CHEMISTRYSELECT; v. 3, n. 6, p. 1719-1726, FEB 14 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
Synthesis, characterization and biological activities of a silver(I) complex with cycloserine (AgCIC) are presented. Elemental, thermal and mass spectrometric analyses permitted proposing the minimal formula AgC3H5N2O2. The structure of the AgCIC complex was solved by powder X-ray diffraction (XRD) studies. Coordination of the ligand to silver was shown to occur by the nitrogen atom of the heterocyclic ring and by the nitrogen and oxygen atoms of the amino and carbonyl groups, leading to a polymeric arrangement. Infrared (IR) and nuclear magnetic resonance (NMR) spectroscopic analyses confirmed the coordination sites. Antibacterial assays revealed the activity of the AgCIC complex against Mycobacterium tuberculosis, with minimal inhibitory concentration (MIC90) of 79.1 molL(-1), and against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa bacterial strains. Antiproliferative assays over a panel of tumoral and non-tumoral cells showed that the AgCIC complex is more active and selective than doxorubicin against breast and leukemia cancer cells, considering the total growth inhibition (TGI) values. The interaction of the complex with biomolecules and its mutagenicity were also investigated. (AU) | |
| FAPESP's process: | 15/09833-0 - Sustainable delivery system based on biocellulose/metallic complexes containing bioactive ligands |
| Grantee: | Wilton Rogério Lustri |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/25114-4 - Synthesis of New Ag(I), Cu(II), Pd(II) and Pt(II) complexes based on sulfonamides and derivatives: antibacterial activities and application prospects on skin critically colonized wounds. |
| Grantee: | Pedro Paulo Corbi |
| Support Opportunities: | Regular Research Grants |