F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect bone cancer at early stage in rodents

Autor(es)

Alves, Christiano R. R. ^{[1, 2]} ; Faria, Daniele de P. ^[3] ; Carneiro, Camila de G. ^[3] ; Garcez, Alexandre T. ^[3] ; Gutierrez, Vanessa P. ^[4] ; das Neves, Willian ^[1] ; de Almeida, Ney R. ^[1] ; Cury, Yara ^[4] ; Chammas, Roger ^[3] ; Brum, Patricia C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

^[2] Harvard Med Sch, Joslin Diabet Ctr, Boston, MA - USA

^[3] Univ Sao Paulo, Dept Radiol & Oncol, Fac Med, Sao Paulo - Brazil

^[4] Butantan Inst, Lab Pain & Signaling, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Life Sciences; v. 206, p. 29-34, AUG 1 2018.
• Citações Web of Science: 0

Resumo

Noninvasive imaging using positron emission tomography/computed tomography (PET/CT) and single photon emission computed tomography/computed tomography (SPECT/CT) are considered revolutionized approaches to detect bone cancer. Both PET/CT and SPECT/CT technologies have advanced to permit miniaturization, which has provided the advantage of including animals as their own controls in longitudinal studies. The present study was designed to evaluate the potential of PET/CT and SPECT/CT as research tools to detect bone cancer in rats. We used a rat model of bone cancer induced by injecting Walker 256 tumor cells into the femoral cavity. Computed tomography demonstrated that rats presented a solid tumor at 15 days post injection (dpi). However, CT was not an effective method for identifying tumors at an earlier time point (8 dpi), when mechanical hyperalgesia (the most common symptom during bone cancer progression) had already initiated. At this early stage, PET/CT and SPECT/CT analysis detected higher uptake in the injected femur of the tracers F-18-Fluoride and Tc-99m-Methyl diphosphonate (Tc-99m-MDP), respectively. These findings demonstrated for the first time that both F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect cancer at early stages in rats and advocates for the PET/SPECT/CT as research tools to evaluate bone cancer in further longitudinal studies involving small animals. (AU)

• Processo FAPESP: 15/22814-5 - Câncer e coração: novos paradigmas de diagnóstico e tratamento
• Beneficiário: Carlos Eduardo Negrão
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/03016-8 - Caquexia do câncer: efeitos do treinamento físico aeróbio sobre o músculo esquelético em modelo animal
• Beneficiário: Christiano Robles Rodrigues Alves
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 16/01478-0 - Mecanismos moleculares da caquexia do câncer: explorando o papel da COPS2
• Beneficiário: Christiano Robles Rodrigues Alves
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 12/02528-0 - Efeitos do treinamento físico aeróbio intervalado em alta intensidade no músculo esquelético de ratos inoculados com o tumor Walker 256
• Beneficiário: Christiano Robles Rodrigues Alves
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 12/25240-1 - Efeitos do treinamento físico aeróbio intervalado em alta intensidade no músculo esquelético de ratos inoculados com o tumor Walker 256
• Beneficiário: Christiano Robles Rodrigues Alves
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado