Effects of benign prostatic hyperplasia and finasteride therapy on prostatic blood flow in dogs

Autor(es)

Angrimani, D. S. R. ^[1] ; Silvestrini, G. R. ^[1] ; Brito, M. M. ^[1] ; Abreu, R. A. ^[1] ; Almeida, L. L. ^[1] ; Vannucchi, I, C.

Afiliação do(s) autor(es)

^[1] I, Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Anim Reprod, Av Prof Orlando Marques de Paiva 87, BR-05508270 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Theriogenology; v. 114, p. 103-108, JUL 1 2018.
• Citações Web of Science: 3

Resumo

Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate accompanied by an increase in prostatic blood perfusion and vascularization. The most indicated treatment is to perform orchiectomy, however, medical treatment with finasteride can be an option for breeding dogs or elderly animals with a critical health status. In dogs, the influence of medical treatment on prostatic hemodynamics is still unknown. Therefore, this study aimed to evaluate the effects of benign prostatic hyperplasia and finasteride therapy on hemodynamic and vascular features of the canine prostate. For this purpose, twenty dogs of different breeds, body weights (10-30 kg) and ages (5-13 years) were used, assigned for: Healthy-non treated group (n = 5), BPH-non treated group (n = 5), Healthy-finasteride treated group (n = 5) and BPH-finasteride treated group (n = 5). Dogs that presented hematospermia and at least one general clinical sign (tenesmus, hematuria or dysuria) were presumptively diagnosed with BPH. Dogs were evaluated ultrasonographycally by B-mode and Doppler of the prostatic artery in a monthly interval (day 0, 30 and 60) in order to measure prostate volume (PV), expected prostate volume (EPV), prostate vascularization score (scored as minimum, intermediary and maximum) and prostatic artery blood flow parameters with the use of spectral and color Doppler ultrasound. It was possible to observe a decrease in prostate vascularization score between Day 0 (intermediary degree) and 60 (minimum degree) in finasteride treated dogs. Moreover, non-treated dogs had higher score of vascularization at Day 60 compared to animals treated with finasteride, regardless of BPH diagnosis. Healthy non treated animals presented higher peak systolic:diastolic velocity (S/D) than BPH-non treated dogs. Furthermore, BPH-non treated dogs had lower S/D than BPH-finasteride treated dogs. In 30 and 60 days, no difference on PV was observed between BPH-finasteride treated group and Healthy-non treated group. At day 60, no difference between PV and EPV was observed for the BPH-finasteride treated group. In conclusion, finasteride treatment reduces simultaneously the volume, local vascularization and blood flow of the prostate, thus, being considered an effective and additional choice of therapy for BPH. Moreover, the course of therapy in dogs can be followed by analyzing changes in prostatic artery. (C) 2018 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 13/25966-5 - Caracterização seminal e das alterações hemodinâmicas da próstata e testículos de cães com hiperplasia prostática benigna
• Beneficiário: Daniel de Souza Ramos Angrimani
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/05419-5 - Senescência reprodutiva em cães: aspectos clínicos e biotecnológicos
• Beneficiário: Camila Infantosi Vannucchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular