Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

Autor(es)

Da Broi, M. G. ^[1] ; Giorgi, V. S. I. ^[1] ; Wang, F. ^[2] ; Keefe, D. L. ^{[3, 2]} ; Albertini, D. ^[4] ; Navarro, P. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Gynecol & Obstet, Div Human Reprod, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] NYU, Dept Obstet & Gynecol, Lab Reprod Med, Sch Med, 180 Varick St, New York, NY 10014 - USA

^[3] NYU, Dept Obstet & Gynecol, Langone Med Ctr, New York, NY 10016 - USA

^[4] Ctr Human Reprod, New York, NY - USA

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS; v. 35, n. 5, p. 735-751, MAY 2018.
• Citações Web of Science: 20

Resumo

An equilibrium needs to be established by the cellular and acellular components of the ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus cells (CCs) and follicular fluid (FF) are critical determinants for oocyte quality. Understanding how CCs and FF influence oocyte quality in the presence of deleterious systemic or pelvic conditions may impact clinical decisions in the course of managing infertility. Given that the functional integrities of FF and CCs are susceptible to concurrent pathological conditions, it is important to understand how pathophysiological factors influence natural fertility and the outcomes of pregnancy arising from the use of assisted reproduction technologies (ARTs). Accordingly, this review discusses the roles of CCs and FF in ensuring oocyte competence and present new insights on pathological conditions that may interfere with oocyte quality by altering the intrafollicular environment. (AU)

• Processo FAPESP: 15/21907-0 - Acurácia do comprimento médio e do comprimento dos menores telômeros de corpúsculos polares de oócitos humanos obtidos após estimulação ovariana controlada para técnicas de reprodução assistida na predição de euploidia e aneuploidias embrionárias
• Beneficiário: Paula Andrea de Albuquerque Salles Navarro
• Modalidade de apoio: Bolsas no Exterior - Pesquisa