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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

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Author(s):
Da Broi, M. G. [1] ; Giorgi, V. S. I. [1] ; Wang, F. [2] ; Keefe, D. L. [3, 2] ; Albertini, D. [4] ; Navarro, P. A. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Gynecol & Obstet, Div Human Reprod, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] NYU, Dept Obstet & Gynecol, Lab Reprod Med, Sch Med, 180 Varick St, New York, NY 10014 - USA
[3] NYU, Dept Obstet & Gynecol, Langone Med Ctr, New York, NY 10016 - USA
[4] Ctr Human Reprod, New York, NY - USA
Total Affiliations: 4
Document type: Review article
Source: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS; v. 35, n. 5, p. 735-751, MAY 2018.
Web of Science Citations: 20
Abstract

An equilibrium needs to be established by the cellular and acellular components of the ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus cells (CCs) and follicular fluid (FF) are critical determinants for oocyte quality. Understanding how CCs and FF influence oocyte quality in the presence of deleterious systemic or pelvic conditions may impact clinical decisions in the course of managing infertility. Given that the functional integrities of FF and CCs are susceptible to concurrent pathological conditions, it is important to understand how pathophysiological factors influence natural fertility and the outcomes of pregnancy arising from the use of assisted reproduction technologies (ARTs). Accordingly, this review discusses the roles of CCs and FF in ensuring oocyte competence and present new insights on pathological conditions that may interfere with oocyte quality by altering the intrafollicular environment. (AU)

FAPESP's process: 15/21907-0 - Accuracy of polar body mean telomere length and polar body shortest telomere length of human oocytes obtained after controlled ovarian stimulation for assisted reproduction techniques in predicting embryonic euploidia and aneuploidy
Grantee:Paula Andrea de Albuquerque Salles Navarro
Support Opportunities: Scholarships abroad - Research