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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Green tea supplementation promotes leukocyte telomere length elongation in obese women

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Autor(es):
Nonino, Carla B. [1] ; Pinhanelli, Vitor Caressato [1] ; Noronha, Natalia Y. [1] ; Quinhoneiro, Driele C. G. [1] ; Souza Pinhel, Marcela A. [1] ; de Oliveira, Bruno A. P. [1] ; Marchini, Julio Sergio [1] ; Nicoletti, Carolina Ferreira [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: NUTRICION HOSPITALARIA; v. 35, n. 3, p. 570-575, MAY-JUN 2018.
Citações Web of Science: 1
Resumo

Abstract Introduction: inflammation and oxidative stress are factors that may play a substantial role in telomere attrition. In line of this, obesity is associated with telomere shortening. Green tea had anti-inflammatory and antioxidant effects and may alter telomere length (TL). Objectives: we evaluated the effect of decaffeinated green tea supplementation in obese women on TL. Methods: we conducted a cross-sectional interventional study with ten obese (body mass index [BMI] > 40 kg/m²) and eight normal weight (BMI > 18.5 and < 24.9 kg/m²) women (age between 27 and 48 years). The supplementation was carried out with capsules (each contained 450.7 mg of epigallocatechin-3-gallate) during eight weeks. Anthropometric and dietary intake assessment, and blood collection (for biochemical and TL analysis by quantitative PCR) were performed before and after supplementation. Normal weight patients were evaluated at a single moment. Results: we observed a significant increase on TL after supplementation (1.57 ± 1.1 to 3.2 ± 2.1 T/Sratio; p < 0.05). Moreover, we found shorter TL in obese patients (day 0) when compared to normal weight individuals (3.2 ± 1.9 T/Sratio; p < 0.05) and an inverse association between TL and BMI, even after age adjustment (beta = -0.527; r² = 0.286; IC = -0.129, -0.009). Conclusion: obesity is related to shorter telomeres. Green tea supplementation during eight weeks promotes telomere elongation in obese women. (AU)

Processo FAPESP: 13/08916-4 - Análise da expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após intervenções para perda de peso
Beneficiário:Carla Barbosa Nonino
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/00669-0 - Análise da expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após a suplementação com chá verde
Beneficiário:Driele Cristina Gomes Quinhoneiro
Modalidade de apoio: Bolsas no Brasil - Mestrado