Accounting for radiation-induced indirect damage on DNA with the Geant 4-DNA code

Autor(es)

Rosales, Liset de la Fuente ^[1] ; Incerti, Sebastien ^[2] ; Francis, Ziad ^[3] ; Bernal, Mario A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Fis Aplicada, Inst Fis Gleb Wataghin, Campinas - Brazil

^[2] Univ Bordeaux, CENBG, UMR 5797, F-33170 Gradignan - France

^[3] Univ St Joseph, Fac Sci, Dept Phys, Beirut - Lebanon

• Tipo de documento: Artigo Científico
• Fonte: PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS; v. 51, p. 108-116, JUL 2018.
• Citações Web of Science: 6

Resumo

The use of Monte Carlo (MC) simulations remains a powerful tool to study the biological effects induced by ionizing radiation on living beings. Several MC codes are commonly used in research fields such as nanodosimetry, radiotherapy, radiation protection, and space radiation. This work presents an enhancement of an existing model {[}1] for radiobiological purposes, to account for the indirect DNA damage induced by ionizing particles. The Geant4-DNA simulation toolkit was used to simulate the physical, pre-chemical, and chemical stages of early DNA damage induced by protons and a-particles. Liquid water was used as the medium for simulations. Two phase-space files were generated, one containing the energy deposition events and another with the position of chemical species produced by water radiolysis from 0.1 ps up to 1 ns. These files were used as input in the radiobiological code that contains the genetic material model with atomic resolution, consisting of several copies of 30 nm chromatin fibers. The B-DNA configuration was used. This work focused on the indirect damage produced by the hydroxyl radical (% OH) attack on the sugar-phosphate group. The approach followed to account for the indirect DNA damage was the same as those used by other radiobiological codes {[}2,3]. The critical parameter considered here was the reaction radius, which was calculated from the Smoluchowski's diffusion equation. Single, double, and total strand break yields produced by direct, indirect, and mixed mechanisms are reported. The obtained results are consistent with experimental and calculation data sets published in the literature. (AU)

• Processo FAPESP: 15/21873-8 - Desenvolvimento e implementação de metodologias para otimização de técnicas de imagens em radiologia digital
• Beneficiário: Alessandra Tomal
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/51594-2 - Desenvolvimento de um sistema computacional para a simulação da interação da radiação ionizante com o material genético humano
• Beneficiário: Mario Antonio Bernal Rodriguez
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores