Sagittal abdominal diameter resembles waist circumference as a surrogate marker of insulin resistance in adolescents-Brazilian Metabolic Syndrome Study

Autor(es)

da Silva, Cleliani de Cassia ^{[1, 2]} ; Vasques, Ana Carolina J. ^{[3, 1, 2]} ; Zambon, Mariana P. ^{[2, 4]} ; Camilo, Daniella F. ^{[1, 2]} ; De Bernardi Rodrigues, Ana Maria ^{[1, 5]} ; Antonio, Maria Angela R. G. M. ^{[2, 4]} ; Geloneze, Bruno ^{[1, 2, 6]} ; Syndrome, Brazilian Metabolic

Afiliação do(s) autor(es)

^[1] Lab Invest Metab & Diabet Limed, Gastroenterol Diag & Res Ctr Gastroctr, 420 Carlos Chagas St, BR-13081970 Campinas, SP - Brazil

^[2] Univ Campinas Unicamp, Fac Med Sci, Postgrad Program Child & Adolescent Hlth, Campinas, SP - Brazil

^[3] Univ Campinas UNICAMP, Sch Appl Sci, Limeira, SP - Brazil

^[4] Univ Campinas Unicamp, Dept Pediat, Campinas, SP - Brazil

^[5] Univ Ctr Our Lady Patronage, Sch Hlth & Life Sci, Itu, SP - Brazil

^[6] Natl Inst Sci & Technol Obes & Diabet, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PEDIATRIC DIABETES; v. 19, n. 5, p. 882-891, AUG 2018.
• Citações Web of Science: 2

Resumo

Objective: To evaluate the association of the sagittal abdominal diameter (SAD) with insulin resistance (IR) and metabolic syndrome (MetS) components, and to compare SAD with waist circumference (WC). Subjects/Methods: This was a multicenter, cross-sectional study of 520 adolescents (10- to 18-years old). IR was assessed using the homeostasis model assessment of IR (HOMA-IR) and the hyperglycaemic clamp (n=76). Results: SAD and WC were positively correlated with HOMA-IR (r=0.637 and r=0.653) and inversely correlated with the clamp-derived insulin sensitivity index (ISI) (r=-0.734 and r=-0.731); P<.001. In the multivariable linear regression analysis, SAD was positively associated with HOMA-IR (B=0.046 +/- 0.003) and inversely associated with the clamp-derived ISI (B=-0.084 +/- 0.009) after adjusting for sex, age, and Tanner's stages (P<.001). When WC replaced the SAD, it was positively associated with HOMA-IR (B=0.011 +/- 0.001) and inversely associated with the clamp-derived ISI (B=-0.018 +/- 0.002); P<.001. The values of the areas under the curves (AUC) were 0.823 and 0.813 for SAD and WC, respectively. In Bland-Altman analysis, there were agreement between both, SAD and WC, with the clamp-derived ISI (mean=0.00; P>.05). The SAD and WC were positively associated with blood pressure, triglycerides, and uric acid, and inversely associated with high-density lipoprotein (HDL)-cholesterol after adjusting for sex, age, and Tanner's stages. Conclusion: The SAD was associated with IR and MetS components, with a good discriminatory power for detecting IR. When compared to WC, SAD showed equivalent results. (AU)

• Processo FAPESP: 13/21476-3 - Validação de métodos substitutivos, laboratoriais e antropométricos, como indicadores de resistência à insulina estudada pelo clamp hiperglicêmico em adolescentes. Brazilian Metabolic Syndrome Study (BRAMS)
• Beneficiário: Cleliani de Cassia da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado