AMPA receptor trafficking and its role in heterosynaptic plasticity

Autor(es)

Antunes, G. ^[1] ; Simoes-de-Souza, F. M. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 8, JUL 9 2018.
• Citações Web of Science: 2

Resumo

Historically, long-term potentiation (LTP) and long-term depression (LTD), the best-characterized forms of long-term synaptic plasticity, are viewed as experience-dependent and input-specific processes. However, cumulative experimental and theoretical data have demonstrated that LTP and LTD can promote compensatory alterations in non-stimulated synapses. In this work, we have developed a computational model of a tridimensional spiny dendritic segment to investigate the role of AMPA receptor (AMPAR) trafficking during synaptic plasticity at specific synapses and its consequences for the populations of AMPAR at nearby synapses. Our results demonstrated that the mechanisms of AMPAR trafficking involved with LTP and LTD can promote heterosynaptic plasticity at non-stimulated synapses. These alterations are compensatory and arise from molecular competition. Moreover, the heterosynaptic changes observed in our model can modulate further activity-driven inductions of synaptic plasticity. (AU)

• Processo FAPESP: 14/08481-0 - Modelo computacional dos mecanismos pós-sinápticos da integração dopaminérgica e glutamatérgica em uma espinha dendrítica hipocampal em condições fisiológicas saudáveis e patológicas
• Beneficiário: Gabriela Antunes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/18825-4 - Computando linguagem com neurônios espelho
• Beneficiário: Fábio Marques Simões de Souza
• Modalidade de apoio: Auxílio à Pesquisa - Parceria para Inovação Tecnológica - PITE
• Processo FAPESP: 15/50122-0 - Fenômenos dinâmicos em redes complexas: fundamentos e aplicações
• Beneficiário: Elbert Einstein Nehrer Macau
• Modalidade de apoio: Auxílio à Pesquisa - Temático