| Texto completo | |
| Autor(es): |
Lima, Leandro Bueno
[1]
;
Haubenthal, Fernanda Tais
[2]
;
Silveira, Marina Augusto
[2]
;
Bohlen, Tabata Mariz
[2]
;
Metzger, Martin
[1]
;
Donato Jr, Jose
;
Frazao, Renato
[2]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Neuroscience Letters; v. 681, p. 12-16, AUG 10 2018. |
| Citações Web of Science: | 3 |
| Resumo | |
A small neuronal subpopulation in the medial nucleus of the amygdala (MeA), expressing the Kiss1 gene, is now considered an important mediator that integrates socio-sexual behavior and odor information in order to modulate the Hypothalamic-Pituitary-Gonadal (HPG) axis. Previous studies demonstrated that exogenous kisspeptin administration or selective activation of Kiss1-expressing neurons in the MeA modulates the onset of puberty, LH secretion and sexual behavior. These functions are supported by the known MeA neuronal connections. In the MeA, as well as in the hypothalamus, Kiss1 mRNA expression mostly depends on sex steroids levels. However, the percentage of Kiss1-expressing cells that co-express estrogen receptor a (ER alpha) in the MeA is currently unknown. Additionally, whether MeA kisspeptin neurons show Fos expression due to pheromone exposure is still undisclosed. In the present study, we used adult male and female mice that express a reporter protein under the Kiss1 promoters to determine the percentage of Kiss1-expressing neurons that co-express the ERa in the MeA and, whether those cells are activated by olfactory cues. We found a high percentage of Kiss1-expressing neurons in the MeA co-expressing the ERa. The proportion of co-expression was similar between male and female mice in diestrus. Interestingly, a low percentage of Kiss1-expressing neurons in the MeA co-express Fos after conspecific odor exposure, despite a significant increase of Fos positive cells in the MeA. Additionally, odor exposition leads to a sexually dimorphic change in Kiss1 expression in the posterior subdivision of the MeA. Our findings suggest that olfactory signals predominantly activate non-kisspeptin cells in the MeA to modulate responses to pheromones and therefore the HPG axis. (AU) | |
| Processo FAPESP: | 12/12202-4 - Modulação das propriedades biofísicas de neurônios Kiss1 por fatores circadianos |
| Beneficiário: | Renata Frazão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/08755-3 - Ativação dos neurônios que expressam o gene Kiss1 mediante à estímulo ferormonal |
| Beneficiário: | Fernanda Tais Haubenthal |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 17/16473-6 - Processamento de estímulos aversivos: circuitaria entre o núcleo tegmental laterodorsal, a habênula, e os núcleos dorsal e mediano da rafe |
| Beneficiário: | Martin Andreas Metzger |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/02983-2 - Ação do hormônio do crescimento no sistema nervoso: relevância para as funções neurais e na doença |
| Beneficiário: | Jose Donato Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 15/14588-5 - Influência da sensibilidade à leptina na maturação sexual de camundongos |
| Beneficiário: | Tabata Mariz Bohlen |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |