Inner and Outer Retinal Contributions to Pupillary Light Response: Correlation to Functional and Morphologic Parameters in Glaucoma

Autor(es)

Duque-Chica, Gloria L. ^{[1, 2]} ; Gracitelli, Carolina P. B. ^[3] ; Moura, Ana L. A. ^{[3, 1]} ; Nagy, Balazs V. ^{[4, 1]} ; Vidal, Kallene S. ^{[1, 5]} ; Paranhos, Jr., Augusto ^[3] ; Ventura, Dora F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Psychol, Expt Psychol Dept, Sao Paulo - Brazil

^[2] Univ Medellin, Dept Psychol, Medellin - Colombia

^[3] Univ Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Sao Paulo - Brazil

^[4] Budapest Univ Technol & Econ, Dept Mechatron Opt & Engn Informat, Budapest - Hungary

^[5] Prevent Senior Inst, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF GLAUCOMA; v. 27, n. 8, p. 723-732, AUG 2018.
• Citações Web of Science: 2

Resumo

Purpose: To evaluate in patients with primary open-angle glaucoma (POAG) the contribution of the inner and outer retinal photo-receptors to the pupillary light responses (PLRs) correlated with both functional (color vision and visual field perimetry) and morphologic (optical coherence tomography) parameters. Methods: In total, 45 patients with POAG and 25 healthy control participants were evaluated. The PLR was measured as pupil diameter with an eye tracker; stimuli were presented in a Ganzfeld. Pupil responses were measured monocularly, to 1 second blue (470 nm) and red (640 nm) flashes with -3, -2, -1, 0, 1, 2, and 2.4 log cd/m(2) luminance levels. Color vision was evaluated with the Cambridge Color Test, visual field was measured by standard automatic perimetry, and retinal nerve fiber layer thickness was evaluated by optical coherence tomography. Results: Patients with moderate and severe POAG have a significantly decreased PLR that depends on the severity of POAG, for both the 470 and 640 nm stimuli, revealing the reduction of the contributions of the rods, cones, and intrinsically photosensitive retinal ganglion cells to PLR. A significant loss of color discrimination along the blue-yellow axis was observed in all stages of POAG. Correlations among standard automatic perimetry, retinal nerve fiber layer thickness, Cambridge Color Test, PLR, and melanopsin parameters were found. Conclusions: The results provide evidence that in moderate and severe stages of POAG, both the inner and outer retinal contributions to PLR are affected. Also, a worsening in color vision was correlated with reduced PLR responses at high-intensity stimuli. These findings may enhance the clinical management of POAG patients. (AU)

• Processo FAPESP: 09/54292-7 - Avaliacao do desempenho visual em diferentes condicoes de iluminacao artificial com caracteristicas espectrais variadas
• Beneficiário: Balazs Vince Nagy
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 08/58731-2 - A visão como indicador de processos lesivos na retina e no sistema nervoso central
• Beneficiário: Dora Selma Fix Ventura
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/03553-0 - Estudo da função da melanopsina através da resposta pupilar à luz na neuropatia óptica e no distúrbio de sono
• Beneficiário: Gloria Liliana Duque Chica
• Modalidade de apoio: Bolsas no Brasil - Doutorado