Inner and Outer Retinal Contributions to Pupillary Light Response: Correlation to Functional and Morphologic Parameters in Glaucoma

Author(s)

Duque-Chica, Gloria L. ^{[1, 2]} ; Gracitelli, Carolina P. B. ^[3] ; Moura, Ana L. A. ^{[3, 1]} ; Nagy, Balazs V. ^{[4, 1]} ; Vidal, Kallene S. ^{[1, 5]} ; Paranhos, Jr., Augusto ^[3] ; Ventura, Dora F. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Psychol, Expt Psychol Dept, Sao Paulo - Brazil

^[2] Univ Medellin, Dept Psychol, Medellin - Colombia

^[3] Univ Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Sao Paulo - Brazil

^[4] Budapest Univ Technol & Econ, Dept Mechatron Opt & Engn Informat, Budapest - Hungary

^[5] Prevent Senior Inst, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF GLAUCOMA; v. 27, n. 8, p. 723-732, AUG 2018.
• Web of Science Citations: 2

Abstract

Purpose: To evaluate in patients with primary open-angle glaucoma (POAG) the contribution of the inner and outer retinal photo-receptors to the pupillary light responses (PLRs) correlated with both functional (color vision and visual field perimetry) and morphologic (optical coherence tomography) parameters. Methods: In total, 45 patients with POAG and 25 healthy control participants were evaluated. The PLR was measured as pupil diameter with an eye tracker; stimuli were presented in a Ganzfeld. Pupil responses were measured monocularly, to 1 second blue (470 nm) and red (640 nm) flashes with -3, -2, -1, 0, 1, 2, and 2.4 log cd/m(2) luminance levels. Color vision was evaluated with the Cambridge Color Test, visual field was measured by standard automatic perimetry, and retinal nerve fiber layer thickness was evaluated by optical coherence tomography. Results: Patients with moderate and severe POAG have a significantly decreased PLR that depends on the severity of POAG, for both the 470 and 640 nm stimuli, revealing the reduction of the contributions of the rods, cones, and intrinsically photosensitive retinal ganglion cells to PLR. A significant loss of color discrimination along the blue-yellow axis was observed in all stages of POAG. Correlations among standard automatic perimetry, retinal nerve fiber layer thickness, Cambridge Color Test, PLR, and melanopsin parameters were found. Conclusions: The results provide evidence that in moderate and severe stages of POAG, both the inner and outer retinal contributions to PLR are affected. Also, a worsening in color vision was correlated with reduced PLR responses at high-intensity stimuli. These findings may enhance the clinical management of POAG patients. (AU)

• FAPESP's process: 08/58731-2 - Vision as a sensitive indicator of conditions threatening retinal and central nervous system function
• Grantee: Dora Selma Fix Ventura
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/03553-0 - Study of the role of melanopsin through the pupillary light response in optic neuropathy and disturbed sleep
• Grantee: Gloria Liliana Duque Chica
• Support Opportunities: Scholarships in Brazil - Doctorate