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Study of the role of melanopsin through the pupillary light response in optic neuropathy and disturbed sleep

Grant number: 13/03553-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2013
Effective date (End): July 31, 2015
Field of knowledge:Humanities - Psychology
Principal Investigator:Dora Selma Fix Ventura
Grantee:Gloria Liliana Duque Chica
Home Institution: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Several studies have shown that intrinsically photosensitive ganglion cells (ipRGCs), a small population of ganglion cells containing the photopigment melanopsin, contribute both to the pupillary light reflex and the circadian rhythm. Nowadays, the evaluation of pupillary light reflex is used in clinical practice to test the operating condition of different retinal cell types. Its properties such as velocity and amplitude of contraction may be related to functional and anatomical losses in optic neuropathies, therefore provides valuable objective information about the functionality of the optic nerve. The loss of retinal ganglion cells in glaucomatous neuropathy allows this disease to be a model for studies of circadian physiology. Furthermore, the key role of luminous information on the generation of biological rhythms is of great interest to determine how ocular diseases can affect the circadian system. This study aims to evaluate the integrity of ganglion cells expressing melanopsin through the pupillary light reflex and to compare it to the level of saliva's melatonin in a group of patients with glaucomatous optic neuropathy, and also in a group of patients with sleep disorders (obstructive sleep apnea) in order to understand the relationship of ipRGCs on the pathogenesis of circadian abnormalities. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DUQUE-CHICA, GLORIA L.; GRACITELLI, CAROLINA P. B.; MOURA, ANA L. A.; NAGY, BALAZS V.; VIDAL, KALLENE S.; DE MELO, GERALDINE; PARANHOS, JR., AUGUSTO; CAHALI, MICHEL B.; VENTURA, DORA F. Contributions of the Melanopsin-Expressing Ganglion Cells, Cones, and Rods to the Pupillary Light Response in Obstructive Sleep Apnea. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 60, n. 8, p. 3002-3012, JUL 2019. Web of Science Citations: 0.
DUQUE-CHICA, GLORIA L.; GRACITELLI, CAROLINA P. B.; MOURA, ANA L. A.; NAGY, BALAZS V.; VIDAL, KALLENE S.; PARANHOS, JR., AUGUSTO; VENTURA, DORA F. Inner and Outer Retinal Contributions to Pupillary Light Response: Correlation to Functional and Morphologic Parameters in Glaucoma. JOURNAL OF GLAUCOMA, v. 27, n. 8, p. 723-732, AUG 2018. Web of Science Citations: 2.
GRACITELLI, CAROLINA P. B.; DUQUE-CHICA, GLORIA LILIAN; DE ARAUJO MOURA, ANA LAURA; ROIZENBLATT, MARINA; NAGY, BALAZS V.; DE MELO, GERALDINE RAGOT; BORBA, PAULA DELEGREGO; TEIXEIRA, SERGIO H.; TUFIK, SERGIO; VENTURA, DORA FIX; PARANHOS, JR., AUGUSTO. Relationship between Daytime Sleepiness and Intrinsically Photosensitive Retinal Ganglion Cells in Glaucomatous Disease. JOURNAL OF OPHTHALMOLOGY, 2016. Web of Science Citations: 9.
GRACITELLI, CAROLINA P. B.; DUQUE-CHICA, GLORIA LILIANA; ROIZENBLATT, MARINA; DE ARAUJO MOURA, ANA LAURA; NAGY, BALAZS V.; DE MELO, GERALDINE RAGOT; BORBA, PAULA DELEGREGO; TEIXEIRA, SERGIO H.; TUFIK, SERGIO; VENTURA, DORA FIX; PARANHOS, JR., AUGUSTO. Intrinsically Photosensitive Retinal Ganglion Cell Activity Is Associated with Decreased Sleep Quality in Patients with Glaucoma. OPHTHALMOLOGY, v. 122, n. 6, p. 1139-1148, JUN 2015. Web of Science Citations: 30.
SMET, KEVIN A. G.; LIN, YANDAN; NAGY, BALAZS V.; NEMETH, ZOLTAN; DUQUE-CHICA, GLORIA L.; QUINTERO, JESUS M.; CHEN, HUNG-SHING; LUO, RONNIER M.; SAFI, MAHDI; HANSELAER, PETER. Cross-cultural variation of memory colors of familiar objects. Optics Express, v. 22, n. 26, p. 32308-32328, DEC 29 2014. Web of Science Citations: 15.
GRACITELLI, CAROLINA P. B.; DUQUE-CHICA, GLORIA L.; MOURA, ANA LAURA; NAGY, BALAZS V.; DE MELO, GERALDINE R.; ROIZENBLATT, MARINA; BORBA, PAULA D.; TEIXEIRA, SERGIO H.; VENTURA, DORA F.; PARANHOS, JR., AUGUSTO. A Positive Association Between Intrinsically Photosensitive Retinal Ganglion Cells and Retinal Nerve Fiber Layer Thinning in Glaucoma. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 55, n. 12, p. 7997-8005, DEC 2014. Web of Science Citations: 26.

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