Microreactor Technology as a Tool for the Synthesis of a Glitazone Drug Intermediate

Autor(es)

Pinheiro, Danilo da Silva ^[1] ; de Oliveira Silva, Renan Rodrigues ^[1] ; Cuesta Calvo, Paulo Victor ^[1] ; da Silva, Milena Fernandes ^[2] ; Converti, Attilio ^[3] ; Alves Palma, Mauri Sergio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Biochem & Pharmaceut Technol, Ave Prof Lineu Prestes 580, Bloco 16, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Fed Pernambuco, Biosci Ctr, Ave Prof Moraes Rego 1235, Cidade Univ, BR-50670420 Recife, PE - Brazil

^[3] Genoa Univ, Dept Civil Chem & Environm Engn, Pole Chem Engn, Via Opera Pia 15, I-16145 Genoa - Italy

• Tipo de documento: Artigo Científico
• Fonte: CHEMICAL ENGINEERING & TECHNOLOGY; v. 41, n. 9, p. 1800-1807, SEP 2018.
• Citações Web of Science: 2

Resumo

One of the bottlenecks in the pharmaceutical industry is drug production scale-up, which can be performed by microreactor technology. Such an approach was applied to the synthesis of (Z)-5-(4-hydroxybenzylidene)thiazolidine-2,4-dione, a bioactive aromatic heterocyclic compound belonging to the class of glitazones. n-Propanol was the best solvent and piperidine the best catalyst for the batch reaction, which was completed in only 5.5h. In the microreactor, the productivity was almost independent of solvent. The microreactor behaved as a plug-flow reactor and operated at a steady state for ten hours without efficiency loss. The results suggest that microreactors may replace batch reactors in scaling up drug production. (AU)

• Processo FAPESP: 14/07757-2 - Microreatores na síntese de fármacos
• Beneficiário: Mauri Sergio Alves Palma
• Modalidade de apoio: Auxílio à Pesquisa - Regular