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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Microreactor Technology as a Tool for the Synthesis of a Glitazone Drug Intermediate

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Author(s):
Pinheiro, Danilo da Silva [1] ; de Oliveira Silva, Renan Rodrigues [1] ; Cuesta Calvo, Paulo Victor [1] ; da Silva, Milena Fernandes [2] ; Converti, Attilio [3] ; Alves Palma, Mauri Sergio [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Biochem & Pharmaceut Technol, Ave Prof Lineu Prestes 580, Bloco 16, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Fed Pernambuco, Biosci Ctr, Ave Prof Moraes Rego 1235, Cidade Univ, BR-50670420 Recife, PE - Brazil
[3] Genoa Univ, Dept Civil Chem & Environm Engn, Pole Chem Engn, Via Opera Pia 15, I-16145 Genoa - Italy
Total Affiliations: 3
Document type: Journal article
Source: CHEMICAL ENGINEERING & TECHNOLOGY; v. 41, n. 9, p. 1800-1807, SEP 2018.
Web of Science Citations: 2
Abstract

One of the bottlenecks in the pharmaceutical industry is drug production scale-up, which can be performed by microreactor technology. Such an approach was applied to the synthesis of (Z)-5-(4-hydroxybenzylidene)thiazolidine-2,4-dione, a bioactive aromatic heterocyclic compound belonging to the class of glitazones. n-Propanol was the best solvent and piperidine the best catalyst for the batch reaction, which was completed in only 5.5h. In the microreactor, the productivity was almost independent of solvent. The microreactor behaved as a plug-flow reactor and operated at a steady state for ten hours without efficiency loss. The results suggest that microreactors may replace batch reactors in scaling up drug production. (AU)

FAPESP's process: 14/07757-2 - Micro-reactors in the synthesis of pharmaceuticals
Grantee:Mauri Sergio Alves Palma
Support type: Regular Research Grants