The relationship between esophageal cancer, chagasic megaesophagus and HPV: myths, tales or reality?

Autor(es)

Munari, Fernanda Franco ^[1] ; Carloni, Adriana Cruvinel ^[1] ; Mariano, Vania Sammartino ^[1] ; Syrjanen, Kari ^[2] ; Reis, Rui Manuel ^{[1, 3, 4]} ; Longatto-Filho, Adhemar ^{[1, 3, 4, 5]}

Afiliação do(s) autor(es)

^[1] Barretos Canc Hosp, Mol Oncol Res Ctr, Sao Paulo - Brazil

^[2] Dept Clin Res Biohit Oyj, Helsinki - Finland

^[3] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Med, Braga - Portugal

^[4] 9ICVS 3Bs PT Govt Associate Lab, Braga - Portugal

^[5] Univ Sao Paulo, Dept Pathol, Med Lab Med Invest LIM 14, Fac Med, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: HISTOLOGY AND HISTOPATHOLOGY; v. 33, n. 11, p. 1135-1149, NOV 2018.
• Citações Web of Science: 1

Resumo

A supposed role for persistent high-risk human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) etiology has been suggested by a number of studies. Concomitantly, megaesophagus induced by the Trypanosoma cruzi cell-cycle activity also shows a potential association with ESCC. This review discusses esophageal cancer and the potential association between chagasic megaesophagus and HPV as risk factors for ESCC development. (AU)

• Processo FAPESP: 15/20077-3 - Detecção de DNA de HPV de alto risco e análises do status mutacional dos genes KRAS e PIK3CA e do painel de citocinas inflamatórias em pacientes com câncer de esôfago e megaesôfago chagásico com e sem câncer
• Beneficiário: Fernanda Franco Munari
• Modalidade de apoio: Bolsas no Brasil - Mestrado