The relationship between esophageal cancer, chagasic megaesophagus and HPV: myths, tales or reality?

Author(s)

Munari, Fernanda Franco ^[1] ; Carloni, Adriana Cruvinel ^[1] ; Mariano, Vania Sammartino ^[1] ; Syrjanen, Kari ^[2] ; Reis, Rui Manuel ^{[1, 3, 4]} ; Longatto-Filho, Adhemar ^{[1, 3, 4, 5]}

Affiliation

^[1] Barretos Canc Hosp, Mol Oncol Res Ctr, Sao Paulo - Brazil

^[2] Dept Clin Res Biohit Oyj, Helsinki - Finland

^[3] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Med, Braga - Portugal

^[4] 9ICVS 3Bs PT Govt Associate Lab, Braga - Portugal

^[5] Univ Sao Paulo, Dept Pathol, Med Lab Med Invest LIM 14, Fac Med, Sao Paulo - Brazil

• Document type: Review article
• Source: HISTOLOGY AND HISTOPATHOLOGY; v. 33, n. 11, p. 1135-1149, NOV 2018.
• Web of Science Citations: 1

Abstract

A supposed role for persistent high-risk human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) etiology has been suggested by a number of studies. Concomitantly, megaesophagus induced by the Trypanosoma cruzi cell-cycle activity also shows a potential association with ESCC. This review discusses esophageal cancer and the potential association between chagasic megaesophagus and HPV as risk factors for ESCC development. (AU)

• FAPESP's process: 15/20077-3 - High-risk HPV DNA detection and analysis of the mutational status of KRAS and PIK3CA genes and inflammatory cytokines panel in patients with esophageal cancer and megaesophagus with and without cancer
• Grantee: Fernanda Franco Munari
• Support Opportunities: Scholarships in Brazil - Master