The hygiene hypothesis at a glance: Early exposures, immune mechanism and novel therapies

Autor(es)

Alexandre-Silva, Gabriel M. ^[1] ; Brito-Souza, Pablo A. ^[1] ; Oliveira, Ana C. S. ^[1] ; Cerni, Felipe A. ^[2] ; Zottich, Umberto ^[1] ; Pucca, Manuela B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Roraima, Med Sch, Boa Vista, RR - Brazil

^[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Acta Tropica; v. 188, p. 16-26, DEC 2018.
• Citações Web of Science: 5

Resumo

The hygiene hypothesis was proposed almost three decades ago. Nevertheless, its mechanism still remains with relevant controversies. Some studies defend that early exposures during childhood to microbes and parasites are key determinants to prevent allergies and autoimmune diseases; however, other studies demonstrated that these early exposures can even potentiate the clinical scenario of the diseases. Based on several studies covering the influences of microbiome, parasites, related theories and others, this review focuses on recent advances in the hygiene hypothesis field. In addition, the main immunological mechanisms underlying the hygiene hypothesis are also discussed. We also strongly encourage that researchers do not consider the hygiene hypothesis as a theory based strictly on hygiene habits, but a theory combining diverse influences, as illustrated in this review as the hygiene hypothesis net. (AU)

• Processo FAPESP: 17/14035-1 - Melhoramento de fragmentos de anticorpos humanos (scFVs) específicos para peçonhas animais
• Beneficiário: Felipe Augusto Cerni
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado