Moesin Involvement in Oral Carcinogenesis of the Lower Lip

Autor(es)

Assao, Agnes ^[1] ; Yoshino, Paula Midori ^[1] ; Malta Medeiros, Maria Carolina ^[1] ; Carvalho, Andre Lopes ^[2] ; Soares, Fernando Augusto ^[3] ; Kowalski, Luiz Paulo ^[4] ; Oliveira, Denise Tostes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Surg Stomatol Pathol & Radiol, Area Pathol, Sao Paulo - Brazil

^[2] Canc Hosp Barretos, Fundacao Pio Inst 12, Barretos, SP - Brazil

^[3] Rede DOr Hosp Network, Pathol Div, Sao Paulo - Brazil

^[4] AC Camargo Canc Hosp, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANTICANCER RESEARCH; v. 38, n. 5, p. 2755-2760, MAY 2018.
• Citações Web of Science: 0

Resumo

Background/Aim: This study analyzed moesin immunoexpression in 91 lip squamous cell carcinomas and its influence in patients' prognosis. Materials and Methods: Moesin immunoexpression was evaluated at the invasive tumor front by a semi-quantitative score method. The association of moesin with the clinicopathological variables was analyzed by the Chi-square test, the survival rates were calculated by Kaplan-Meier and the survival curves compared using the log-rank test. Results: The expression of moesin was strong at the invasive tumor front and weak/negative in differentiated cells such as keratin pearls. There was no association between moesin expression and the clinicopathological variables, but there was a tendency for patients with lip cancer and strong moesin expression to have lower 5- and 10-year overall and disease-free survival rates. Conclusion: Our results confirm the participation of moesin in oral carcinogenesis and suggest that this protein can influence the survival rates of patients with lip squamous cell carcinoma. (AU)

• Processo FAPESP: 14/23236-2 - Expressão de moesina como fator de prognóstico em carcinoma espinocelular de lábio
• Beneficiário: Maria Carolina Malta Medeiros
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/13411-6 - Participação da podoplanina no processo de remodelação celular em tumores odontogênicos benignos e tumores epiteliais malignos de boca
• Beneficiário: Denise Tostes Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular