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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Moesin Involvement in Oral Carcinogenesis of the Lower Lip

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Author(s):
Assao, Agnes [1] ; Yoshino, Paula Midori [1] ; Malta Medeiros, Maria Carolina [1] ; Carvalho, Andre Lopes [2] ; Soares, Fernando Augusto [3] ; Kowalski, Luiz Paulo [4] ; Oliveira, Denise Tostes [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Surg Stomatol Pathol & Radiol, Area Pathol, Sao Paulo - Brazil
[2] Canc Hosp Barretos, Fundacao Pio Inst 12, Barretos, SP - Brazil
[3] Rede DOr Hosp Network, Pathol Div, Sao Paulo - Brazil
[4] AC Camargo Canc Hosp, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ANTICANCER RESEARCH; v. 38, n. 5, p. 2755-2760, MAY 2018.
Web of Science Citations: 0
Abstract

Background/Aim: This study analyzed moesin immunoexpression in 91 lip squamous cell carcinomas and its influence in patients' prognosis. Materials and Methods: Moesin immunoexpression was evaluated at the invasive tumor front by a semi-quantitative score method. The association of moesin with the clinicopathological variables was analyzed by the Chi-square test, the survival rates were calculated by Kaplan-Meier and the survival curves compared using the log-rank test. Results: The expression of moesin was strong at the invasive tumor front and weak/negative in differentiated cells such as keratin pearls. There was no association between moesin expression and the clinicopathological variables, but there was a tendency for patients with lip cancer and strong moesin expression to have lower 5- and 10-year overall and disease-free survival rates. Conclusion: Our results confirm the participation of moesin in oral carcinogenesis and suggest that this protein can influence the survival rates of patients with lip squamous cell carcinoma. (AU)

FAPESP's process: 14/23236-2 - Moesin immunoexpresion as prognostic factor in oral squamous cell carcinoma of the lip
Grantee:Maria Carolina Malta Medeiros
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/13411-6 - The role of podoplanin in the process of cellular remodelling in benign odontogenic tumors and oral malignant epithelial tumors
Grantee:Denise Tostes Oliveira
Support Opportunities: Regular Research Grants