Effect of male-specific childhood trauma on telomere length

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Xavier, Gabriela ^{[1, 2]} ; Spindola, Leticia M. ^{[3, 1, 2]} ; Ota, Vanessa K. ^{[1, 2]} ; Carvalho, Carolina M. ^{[3, 1, 2]} ; Maurya, Pawan Kumar ^{[2, 4]} ; Tempaku, Priscila F. ^[5] ; Moretti, Patricia N. ^{[6, 2]} ; Mazotti, Diego R. ^[7] ; Sato, Joao Ricardo ^[8] ; Brietzke, Elisa ^[9] ; Miguel, Euripedes Constantino ^[10] ; Grassi-Oliveira, Rodrigo ^{[11, 12]} ; Mari, Jair ^{[3, 2]} ; Bressan, Rodrigo A. ^{[3, 2]} ; Gadelha, Ary ^{[3, 2]} ; Pan, Pedro M. ^{[3, 2]} ; Belangero, Sintia Iole ^{[3, 1, 2]}

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^[1] Univ Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Genet Div, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci, LiNC, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[4] Cent Univ Haryana, Dept Biochem, Mahendergarh, Haryana - India

^[5] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

^[6] Univ Brasilia UNB, Dept Genet & Morphol, Brasilia, DF - Brazil

^[7] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA

^[8] Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre - Brazil

^[9] Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo - Brazil

^[10] Univ Sao Paulo, Fac Med USP, Dept Psychiat, Sao Paulo - Brazil

^[11] Pontificia Univ Catolica Rio Grande Sul PUCRS, Postgrad Program Psychol, Porto Alegre, RS - Brazil

^[12] Pontificia Univ Catolica Rio Grande do Sul, Dev Cognit Neurosci Lab, Porto Alegre, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PSYCHIATRIC RESEARCH; v. 107, p. 104-109, DEC 2018.
• Citações Web of Science: 2

Resumo

Child maltreatment (CM) is a global issue with serious lifelong consequences. In fact, maltreatment during childhood might be an important risk factor for the development of psychiatric disorders. Furthermore, previous studies showed a strong relationship between telomere length (TL) and early life stress. Considering that only a few studies have evaluated this relationship in children and that even fewer considered the sex as a possible moderator, we investigated whether TL in the blood of both children and adolescents was associated with psychopathology and with a history of CM, and whether these associations were moderated by the sex. In this cross-sectional study, 561 individuals (ranging between 6 and 14 years of age) from a large prospective community school-based study, i.e., the Brazilian High-Risk Cohort (HRC), were evaluated. The Child Behavior Checklist (CBCL) score was used to assess psychopathology, whereas a latent variable encompassing some questions about history of adverse environment and trauma was employed to determine the CM history. TL was measured in blood cells using a multiplex quantitative polymerase chain reaction. Additionally, TL was inserted in two moderation models, in which the CBCL score/CM, TL and sex were the independent variables, the outcome, and the moderator variable, respectively. Although an association between psychiatric symptoms and TL was not observed, a relation between CM and TL moderated by the sex was seen, indicating that males with higher CM scores presented with shorter telomeres than did females. Our results suggest that child maltreatment could influence telomere length in both children and adolescents and that this effect is mediated by the sex. (AU)

• Processo FAPESP: 16/19462-2 - O papel dos miRNAs na esquizofrenia: do genoma à proteína
• Beneficiário: Gabriela Xavier
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 11/50740-5 - Prevenção na esquizofrenia e no transtorno bipolar da neurociência à comunidade: uma plataforma multifásica, multimodal e translacional para investigação e intervenção
• Beneficiário: Rodrigo Affonseca Bressan
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/12559-5 - Transtorno de estresse pós-traumático e neuroprogressão: novas abordagens na compreensão do efeito da violência no funcionamento mental
• Beneficiário: Marcelo Feijó de Mello
• Modalidade de apoio: Auxílio à Pesquisa - Temático