Essential oils from Tithonia diversifolia display potent anti-oedematogenic effects and inhibit acid production by cariogenic bacteria

Autor(es)

Sousa, Ingrid Pontes ^[1] ; Chagas-Paula, Daniela Aparecida ^[1] ; Jorge Tiossi, Renata Fabiane ^[1] ; Silva, Eliane de Oliveira ^[1] ; Miranda, Mariza Abreu ^[1] ; de Oliveira, Rejane Barbosa ^[1] ; Cropanese Spadaro, Augusto Cesar ^[1] ; Bastos, Jairo Kenupp ^[1] ; Jacometti Cardoso Furtado, Niege Aracari ^[1] ; Da Costa, Fernando Batista ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Essential Oil Research; v. 31, n. 1, p. 43-52, JAN 2 2019.
• Citações Web of Science: 1

Resumo

Tithonia diversifolia is an invasive shrub found in the tropical regions. The aim of this study was to investigate the chemical composition as well as anti-inflammatory and antibacterial activities of the essential oils from leaves (EOL) and inflorescences (EOI) of T. diversifolia. The essential oils (EOs) were analysed by gas chromatography with flame ionization detector and coupled with mass spectrometry. EOL and EOI are mainly composed of alpha-pinene and beta-pinene. Both EOL and EOI displayed potent anti-oedematogenic properties at concentrations starting at 0.5 and 2.5% (v/v), respectively. Similar to non-steroidal anti-inflammatory drugs, both EOs inhibited oedema but did not inhibit cellular recruitment. EOI displayed more potent antimicrobial activity against cariogenic microorganisms than EOL. Both EOs significantly inhibited the production of acids by Streptococcus mutans at concentrations that were nontoxic to human gingival fibroblasts (concentrations from 25 to 125 mu g/mL for EOL and from 25 to 250 mu g/mL for EOI). (AU)

• Processo FAPESP: 08/57149-8 - Potencial químico e farmacológico de espécies da familia Asteraceae: estudos integrados in vivo, in vitro e in silico
• Beneficiário: Fernando Batista da Costa
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/01429-8 - Avaliação da atividade de óleos essenciais sobre micro-organismos bucais e efeito de formulação de enxaguatório bucal contendo óleo essencial sobre biofilme de microrganismo cariogênico
• Beneficiário: Ingrid Pontes de Sousa
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 08/02185-0 - Atividade antiinflamatória e caracterização fitoquímica do chá e diferentes extratos de Tithonia diversifolia (Asteraceae)
• Beneficiário: Daniela Aparecida Chagas de Paula
• Modalidade de apoio: Bolsas no Brasil - Mestrado