Essential oils from Tithonia diversifolia display potent anti-oedematogenic effects and inhibit acid production by cariogenic bacteria

Author(s)

Sousa, Ingrid Pontes ^[1] ; Chagas-Paula, Daniela Aparecida ^[1] ; Jorge Tiossi, Renata Fabiane ^[1] ; Silva, Eliane de Oliveira ^[1] ; Miranda, Mariza Abreu ^[1] ; de Oliveira, Rejane Barbosa ^[1] ; Cropanese Spadaro, Augusto Cesar ^[1] ; Bastos, Jairo Kenupp ^[1] ; Jacometti Cardoso Furtado, Niege Aracari ^[1] ; Da Costa, Fernando Batista ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto - Brazil

• Document type: Journal article
• Source: Journal of Essential Oil Research; v. 31, n. 1, p. 43-52, JAN 2 2019.
• Web of Science Citations: 1

Abstract

Tithonia diversifolia is an invasive shrub found in the tropical regions. The aim of this study was to investigate the chemical composition as well as anti-inflammatory and antibacterial activities of the essential oils from leaves (EOL) and inflorescences (EOI) of T. diversifolia. The essential oils (EOs) were analysed by gas chromatography with flame ionization detector and coupled with mass spectrometry. EOL and EOI are mainly composed of alpha-pinene and beta-pinene. Both EOL and EOI displayed potent anti-oedematogenic properties at concentrations starting at 0.5 and 2.5% (v/v), respectively. Similar to non-steroidal anti-inflammatory drugs, both EOs inhibited oedema but did not inhibit cellular recruitment. EOI displayed more potent antimicrobial activity against cariogenic microorganisms than EOL. Both EOs significantly inhibited the production of acids by Streptococcus mutans at concentrations that were nontoxic to human gingival fibroblasts (concentrations from 25 to 125 mu g/mL for EOL and from 25 to 250 mu g/mL for EOI). (AU)

• FAPESP's process: 12/01429-8 - Evaluation of essential oils activity against oral microorganisms and effect of mouthwash containing essential oil upon cariogenic microorganism biofilm
• Grantee: Ingrid Pontes de Sousa
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 08/02185-0 - Anti-inflammatory activity and phitochemical characterization of tea and differents extracts of Tithonia diversifolia (Asteraceae)
• Grantee: Daniela Aparecida Chagas de Paula
• Support Opportunities: Scholarships in Brazil - Master