Low plasma concentrations of N-methyl-D-aspartate receptor subunits as a possible biomarker for psychosis

Autor(es)

Loureiro, C. M. ^[1] ; Shuhama, R. ^[2] ; Fachim, H. A. ^{[3, 2]} ; Menezes, P. R. ^[4] ; Del-Ben, C. M. ^[2] ; Louzada-Junior, P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Clin Immunol, Dept Internal Med, Ave Bandeirantes 3900, BR-14040030 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Psychiat, Dept Neurosci & Behav, Ribeirao Preto, SP - Brazil

^[3] Inst Neurosci & Behav INeC, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Fac Med, Dept Prevent Med, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCHIZOPHRENIA RESEARCH; v. 202, p. 55-63, DEC 2018.
• Citações Web of Science: 2

Resumo

Background: N-methyl-n-aspartate receptor (NMDAR) has been largely implicated in the neurobiology of schizophrenia and other psychosis. Aiming to evaluate their potential as peripheral biomarkers for psychosis, we quantified the plasma concentrations of NR1 and NR2 NMDAR subunits of first-episode psychosis patients in their first contact with mental health services due to psychotic symptoms, compared with siblings and matched community-based controls. Methods: The quantifications of NR1 and NR2 plasma concentrations were performed by ELISA. Data were analysed by nonparametric tests and Receiver Operating Curve (ROC) analysis. Results: We induded 166 first-episode psychosis patients (mean age = 30.3 +/- 12.2 years; 64% men), with the diagnosis of schizophrenia spectrum (n = 84), bipolar disorder (n = 51) and psychotic depression (n = 31), 76 siblings (mean age = 31.5 +/- 11.0 years; 30.3% men) and 166 healthy community-based controls (mean age = 31.4 +/- 12.0 years; 63.9% men). NMDAR subunits were significantly lower in patients compared with siblings and controls (p < 0.001), except by NR1 plasma concentrations of bipolar patients compared with siblings and controls. NR1 plasma concentrations lower than 17.65 pg/ml (AUC = 0.621) showed sensitivity of 42.8%, specificity of 84.3%, positive predictive value (PPV) of 73.2% and negative predictive value (NPV) of 59.6%. Individuals with NR2 plasma concentrations lower than 2.92 ng/ml (AUC = 0.801) presented a 10.61-fold increased risk of psychosis, with a sensibility of 71.9%, specificity of 80.6%, PPV of 79.0% and NPV of 73.9%. Conclusions: This is the first study reporting the measurement and the reduction of NR1 and NR2 NMDAR subunits plasma concentrations in psychiatric disorders. In particular, the NR2 subunit may be a possible plasma biomarker for psychosis. (C) 2018 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/05178-0 - Esquizofrenia e outros transtornos psicóticos: determinantes sociais e biológicos
• Beneficiário: Paulo Rossi Menezes
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias
• Beneficiário: Fernando de Queiroz Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs