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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Vitamin E supplementation and caloric restriction promotes regulation of insulin secretion and glycemic homeostasis by different mechanisms in rats

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Autor(es):
Venturini, Paula R. [1] ; Thomazini, Bruna Fontana [1] ; Oliveira, Camila Andrea [1] ; Alves, Armindo A. [1] ; Camargo, Thais Furtado [1] ; Domingues, Caio E. C. [2] ; Barbosa-Sampaio, Helena C. L. [3] ; do Amaral, Maria Esmeria C. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Ctr Univ Herminio Ometto, UNIARARAS, Grad Program Biomed Sci, Sao Paulo - Brazil
[2] Ctr Univ Herminio Ometto, UNIARARAS, Sch Biol, Sao Paulo - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: BIOCHEMISTRY AND CELL BIOLOGY; v. 96, n. 6, p. 777-785, DEC 2018.
Citações Web of Science: 0
Resumo

Vitamin E and caloric restriction have antioxidant effects in mammals. The aim of this study was to evaluate effects of vitamin E supplementation and caloric restriction upon insulin secretion and glucose homeostasis in rats. Male Wistar rats were distributed among the following groups: C, control group fed ad libitum; R, food quantity reduction of 40%; CV, control group supplemented with vitamin E {[}30 mg.kg(-1).day(-1)]; and RV, food-restricted group supplemented with vitamin E. The experiments ran for 21 days. Glucose tolerance and insulin sensitivity was higher in the CV, R, and RV groups. Insulin secretion stimulated with different glucose concentrations was lower in the R and RV groups, compared with C and CV. In the presence of glucose and secretagogues, insulin secretion was higher in the CV group and was lower in the R and RV groups. An increase in insulin receptor occurred in the fat pad and muscle tissue of groups CV, R, and RV. Levels of hepatic insulin receptor and phospho-Akt protein were higher in groups R and RV, compared with C and CV, while muscle phospho-Akt was increased in the CV group. There was a reduction in hepatic RNA levels of the hepatocyte growth factor gene and insulin degrading enzyme in the R group, and increased levels of insulin degrading enzyme in the CV and RV groups. Thus, vitamin E supplementation and caloric restriction modulate insulin secretion by different mechanisms to maintain glucose homeostasis. (AU)

Processo FAPESP: 12/01146-6 - Efeito da vitamina E na ação e secreção da insulina em animais submetidos à restrição calórica
Beneficiário:Maria Esméria Corezola do Amaral
Modalidade de apoio: Auxílio à Pesquisa - Regular