| Texto completo | |
| Autor(es): |
Speretta, Guilherme F.
[1]
;
Lemes, Eduardo Vieira
[1]
;
Vendramini, Regina C.
[2]
;
Menani, Jose V.
[1]
;
Zoccal, Daniel B.
[1]
;
Colombari, Eduardo
[1]
;
Colombari, Debora S. A.
[1]
;
Bassi, Mirian
[1, 3]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, Rua Humaita 1680, BR-14801903 Araraquara, SP - Brazil
[2] UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, SP - Brazil
[3] Fed Univ Santa Catarina UFSC, Biol Sci Ctr, Dept Physiol Sci, Rua Roberto Sampaio Gonzaga S-N, BR-88040900 Florianopolis, SC - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Respiratory Physiology & Neurobiology; v. 258, p. 32-39, DEC 2018. |
| Citações Web of Science: | 1 |
| Resumo | |
Breathing disorders are commonly observed in association with obesity. Here we tested whether high-fat diet (HFD) impairs the chemoreflex ventilatory response. Male Holtzman rats (300-320g) were fed with standard chow diet (SD) or HFD for 12 weeks. Then, tidal volume (V-T), respiratory frequency (f(R)) and pulmonary ventilation (V-E) were determined in conscious rats during basal condition, hypercapnia (7% or 10% CO2) or hypoxia (7% O-2). The mean arterial pressure (MAP), heart rate (HR) and baroreflex sensitivity were also evaluated in conscious rats. A group of anesthetized rats was used for the measurements of the activity of inspiratory (diaphragm) and expiratory (abdominal) muscles under the same gas conditions. Baseline f(R), V-T and V-E were similar between SD and HFD rats. During hypercapnia, the increase of f(R) was exacerbated in conscious HFD rats (60 +/- 3, vs. SD: 47 +/- 3 Delta breaths.min(-1), P < 0.05). In anesthetized rats, hypercapnia strongly increased abdominal muscle activity in HFD group (238 +/- 27, vs. basal condition: 100 +/- 0.3%; P < 0.05), without significant change in SD group (129 +/- 2.1, vs. basal condition: 100 +/- 0.8%; P = 0.34). The ventilatory responses to hypoxia were similar between groups. In conscious HFD rats, MAP and HR were elevated and the baroreflex function was impaired (P < 0.05). These data demonstrated that 12 weeks of HFD exaggerate the ventilatory response activated by hypercapnia. The mechanisms involved in these responses need more in-vestigation in future studies. (AU) | |
| Processo FAPESP: | 13/17251-6 - Mecanismos neurais de geração do padrão respiratório e do acoplamento simpático-respiratório em condições de hipóxia |
| Beneficiário: | Daniel Breseghello Zoccal |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 13/13118-0 - Participação do sistema melanocortina e sistema renina-angiotensina nas alterações cardiorrespiratórias em ratos submetidos à dieta hiperlipídica |
| Beneficiário: | Guilherme Fleury Fina Speretta |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 13/14850-6 - Função colinérgica cardiorrespiratória no núcleo do trato solitário |
| Beneficiário: | André Luis Aguiar Silva |
| Modalidade de apoio: | Bolsas no Brasil - Programa Capacitação - Treinamento Técnico |