Inflammation induced by influenza virus impairs human innate immune control of pneumococcus

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Jochems, Simon P. ^[1] ; Marcon, Fernando ^[2] ; Carniel, Beatriz F. ^[1] ; Holloway, Mark ^[1] ; Mitsi, Elena ^[1] ; Smith, Emma ^[1] ; Gritzfeld, Jenna F. ^[1] ; Solorzano, Carla ^[1] ; Reine, Jesus ^[1] ; Pojar, Sherin ^[1] ; Nikolaou, Elissavet ^[1] ; German, Esther L. ^[1] ; Hyder-Wright, Angie ^{[1, 3]} ; Hill, Helen ^{[1, 3]} ; Hales, Caz ^{[1, 3]} ; Piters, Wouter A. A. de Steenhuijsen ^{[4, 5, 6]} ; Bogaert, Debby ^{[4, 5, 6]} ; Adler, Hugh ^[1] ; Zaidi, Seher ^[1] ; Connor, Victoria ^{[1, 3]} ; Gordon, Stephen B. ^{[1, 7]} ; Rylance, Jamie ^[1] ; Nakaya, Helder I. ^[2] ; Ferreira, Daniela M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Liverpool, Merseyside - England

^[2] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Analyses, Sao Paulo - Brazil

^[3] Royal Liverpool & Broadgreen Univ Hosp, Liverpool, Merseyside - England

^[4] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht - Netherlands

^[5] Univ Edinburgh, Ctr Inflammat Res, Edinburgh, Midlothian - Scotland

^[6] Univ Med Ctr Utrecht, Dept Paediat Immunol & Infect Dis, Utrecht - Netherlands

^[7] Malawi Liverpool Wellcome Trust Clin Res Programm, Blantyre - Malawi

• Tipo de documento: Artigo Científico
• Fonte: NATURE IMMUNOLOGY; v. 19, n. 12, p. 1299+, DEC 2018.
• Citações Web of Science: 13

Resumo

Colonization of the upper respiratory tract by pneumococcus is important both as a determinant of disease and for transmission into the population. The immunological mechanisms that contain pneumococcus during colonization are well studied in mice but remain unclear in humans. Loss of this control of pneumococcus following infection with influenza virus is associated with secondary bacterial pneumonia. We used a human challenge model with type 6B pneumococcus to show that acquisition of pneumococcus induced early degranulation of resident neutrophils and recruitment of monocytes to the nose. Monocyte function was associated with the clearance of pneumococcus. Prior nasal infection with live attenuated influenza virus induced inflammation, impaired innate immune function and altered genome-wide nasal gene responses to the carriage of pneumococcus. Levels of the cytokine CXCL10, promoted by viral infection, at the time pneumococcus was encountered were positively associated with bacterial load. (AU)

• Processo FAPESP: 12/19278-6 - Biologia de sistemas de longos RNAs não-codificadores
• Beneficiário: Helder Takashi Imoto Nakaya
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias
• Beneficiário: Fernando de Queiroz Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs