Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inflammation induced by influenza virus impairs human innate immune control of pneumococcus

Full text
Author(s):
Show less -
Jochems, Simon P. [1] ; Marcon, Fernando [2] ; Carniel, Beatriz F. [1] ; Holloway, Mark [1] ; Mitsi, Elena [1] ; Smith, Emma [1] ; Gritzfeld, Jenna F. [1] ; Solorzano, Carla [1] ; Reine, Jesus [1] ; Pojar, Sherin [1] ; Nikolaou, Elissavet [1] ; German, Esther L. [1] ; Hyder-Wright, Angie [1, 3] ; Hill, Helen [1, 3] ; Hales, Caz [1, 3] ; Piters, Wouter A. A. de Steenhuijsen [4, 5, 6] ; Bogaert, Debby [4, 5, 6] ; Adler, Hugh [1] ; Zaidi, Seher [1] ; Connor, Victoria [1, 3] ; Gordon, Stephen B. [1, 7] ; Rylance, Jamie [1] ; Nakaya, Helder I. [2] ; Ferreira, Daniela M. [1]
Total Authors: 24
Affiliation:
[1] Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Liverpool, Merseyside - England
[2] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Analyses, Sao Paulo - Brazil
[3] Royal Liverpool & Broadgreen Univ Hosp, Liverpool, Merseyside - England
[4] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht - Netherlands
[5] Univ Edinburgh, Ctr Inflammat Res, Edinburgh, Midlothian - Scotland
[6] Univ Med Ctr Utrecht, Dept Paediat Immunol & Infect Dis, Utrecht - Netherlands
[7] Malawi Liverpool Wellcome Trust Clin Res Programm, Blantyre - Malawi
Total Affiliations: 7
Document type: Journal article
Source: NATURE IMMUNOLOGY; v. 19, n. 12, p. 1299+, DEC 2018.
Web of Science Citations: 13
Abstract

Colonization of the upper respiratory tract by pneumococcus is important both as a determinant of disease and for transmission into the population. The immunological mechanisms that contain pneumococcus during colonization are well studied in mice but remain unclear in humans. Loss of this control of pneumococcus following infection with influenza virus is associated with secondary bacterial pneumonia. We used a human challenge model with type 6B pneumococcus to show that acquisition of pneumococcus induced early degranulation of resident neutrophils and recruitment of monocytes to the nose. Monocyte function was associated with the clearance of pneumococcus. Prior nasal infection with live attenuated influenza virus induced inflammation, impaired innate immune function and altered genome-wide nasal gene responses to the carriage of pneumococcus. Levels of the cytokine CXCL10, promoted by viral infection, at the time pneumococcus was encountered were positively associated with bacterial load. (AU)

FAPESP's process: 12/19278-6 - Systems biology of long non-coding RNAs
Grantee:Helder Takashi Imoto Nakaya
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
Grantee:Fernando de Queiroz Cunha
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC